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Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.

Author(s): Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Front Hum Neurosci. 2015;9:66 Authors: Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Article GUID: 25741267
Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.

Author(s): Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Can J Cardiol. 2016 Apr;32(4):539-46 Authors: Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Article GUID: 26577897
Cognitive function in patients with stable coronary heart disease: Related cerebrovascular and cardiovascular responses.

Author(s): Gayda M, Gremeaux V, Bherer L, Juneau M, Drigny J, Dupuy O, Lapierre G, Labelle V, Fortier A, Nigam A

PLoS One. 2017;12(9):e0183791 Authors: Gayda M, Gremeaux V, Bherer L, Juneau M, Drigny J, Dupuy O, Lapierre G, Labelle V, Fortier A, Nigam A

Article GUID: 28937981
Title:Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.
Authors:Gayda M,  Desjardins A,  Lapierre G,  Dupuy O,  Fraser S,  Bherer L,  Juneau M,  White M,  Gremeaux V,  Labelle V,  Nigam A
Link:https://www.ncbi.nlm.nih.gov/pubmed/26577897?dopt=Abstract
DOI:10.1016/j.cjca.2015.07.011
Category:Can J Cardiol
PMID:26577897
Dept Affiliation: PERFORM
1 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada. Electronic address: mathieu.gayda@icm-mhi.org.
2 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada.
3 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada.
4 Laboratory, MOVE (EA6314), Faculty of Sport Sciences, Université de Poitiers, Poitiers, France.
5 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; The School of Social Work, McGill University, Montréal, Québec, Canada.
6 Department of Psychology, Perform Centre, Concordia University, Montréal, Québec, Canada; Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.
7 Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada.
8 CIC INSERM 1432, Plateforme d'Investigation Technologique, Dijon University Hospital, Dijon, France.
9 Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.

Description:

Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.

Can J Cardiol. 2016 Apr;32(4):539-46

Authors: Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Abstract

BACKGROUND: The aims of this work were (1) to compare cerebral oxygenation-perfusion (COP), central hemodynamics, and peak oxygen uptake (V?o2peak) in heart transplant recipients (HTRs) vs age-matched healthy controls (AMHCs) during exercise and recovery and (2) to study the relationships between COP, central hemodynamics, and V?o2peak in HTRs and AMHCs.

METHODS: Twenty-six HTRs (3 women) and 27 AMHCs (5 women) were recruited. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamics (impedance cardiography), and left frontal COP (near-infrared spectroscopy) were measured continuously during and after a maximal ergocycle (Ergoline 800S, Bitz, Germany) test.

RESULTS: Compared with AMHCs, HTRs had lower V?o2peak, maximal cardiac index (CImax), and maximal ventilatory variables (P < 0.05). COP was lower during exercise (oxyhemoglobin [?O2Hb], 50% and 75% of V?O2peak, total hemoglobin [?tHb], 100% of V?O2peak; P < 0.05), and recovery in HTRs (?O2Hb, minutes 2-5; ?tHb, minutes 1-5; P < 0.05) compared with AMHCs. End-tidal pressure of CO2 was lower during exercise compared with that in AMHCs (P < 0.0001). In HTRs, CImax was positively correlated with exercise cerebral hemodynamics (R = 0.54-0.60; P < 0.01).

CONCLUSIONS: In HTRs, COP was reduced during exercise and recovery compared with that in AMHCs, potentially because of a combination of blunted cerebral vasodilation by CO2, cerebrovascular dysfunction, reduced cardiac function, and medication. The impaired V?O2peak observed in HTRs was mainly caused by reduced maximal ventilation and CI. In HTRs, COP is impaired and is correlated with cardiac function, potentially impacting cognitive function. Therefore, we need to study which interventions (eg, exercise training) are most effective for improving or normalizing (or both) COP during and after exercise in HTRs.

PMID: 26577897 [PubMed - indexed for MEDLINE]