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Ageism and COVID-19: What does our society's response say about us?

Author(s): Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beauli...

Age Ageing. 2020 May 06;: Authors: Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beaulieu M, Berge...

Article GUID: 32377666
Guidelines for Gait Assessments in the Canadian Consortium on Neurodegeneration in Aging (CCNA).

Author(s): Cullen S, Montero-Odasso M, Bherer L, Almeida Q, Fraser S, Muir-Hunter S, Li K, Liu-Ambrose T, McGibbon CA, McIlroy W, Middleton LE, Sarquis...

Can Geriatr J. 2018 Jun;21(2):157-165 Authors: Cullen S, Montero-Odasso M, Bherer L, Almeida Q, Fraser S, Muir-Hunter S, Li K, Liu-Ambrose T, McGibbon CA, McIlroy W, Middleton LE, Sarquis-Adamson ...

Article GUID: 29977431
SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment.

Author(s): Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais ...

BMC Geriatr. 2018 04 16;18(1):93 Authors: Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini...

Article GUID: 29661156
Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA).

Author(s): Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleto...

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):897-909 Authors: Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W...

Article GUID: 30101279
Age-related decline in divided-attention: from theoretical lab research to practical real-life situations.

Author(s): Fraser S, Bherer L

Wiley Interdiscip Rev Cogn Sci. 2013 Nov;4(6):623-640 Authors: Fraser S, Bherer L

Article GUID: 26304268
The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults.

Author(s): Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L

Eur J Appl Physiol. 2015 Oct;115(10):2189-97 Authors: Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L

Article GUID: 26063061
Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.

Author(s): Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Can J Cardiol. 2016 Apr;32(4):539-46 Authors: Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Article GUID: 26577897
Title:Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.
Authors:Gayda M,  Desjardins A,  Lapierre G,  Dupuy O,  Fraser S,  Bherer L,  Juneau M,  White M,  Gremeaux V,  Labelle V,  Nigam A
Link:https://www.ncbi.nlm.nih.gov/pubmed/26577897?dopt=Abstract
DOI:10.1016/j.cjca.2015.07.011
Category:Can J Cardiol
PMID:26577897
Dept Affiliation: PERFORM
1 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada. Electronic address: mathieu.gayda@icm-mhi.org.
2 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada.
3 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada.
4 Laboratory, MOVE (EA6314), Faculty of Sport Sciences, Université de Poitiers, Poitiers, France.
5 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; The School of Social Work, McGill University, Montréal, Québec, Canada.
6 Department of Psychology, Perform Centre, Concordia University, Montréal, Québec, Canada; Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.
7 Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada.
8 CIC INSERM 1432, Plateforme d'Investigation Technologique, Dijon University Hospital, Dijon, France.
9 Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.

Description:

Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.

Can J Cardiol. 2016 Apr;32(4):539-46

Authors: Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Abstract

BACKGROUND: The aims of this work were (1) to compare cerebral oxygenation-perfusion (COP), central hemodynamics, and peak oxygen uptake (V?o2peak) in heart transplant recipients (HTRs) vs age-matched healthy controls (AMHCs) during exercise and recovery and (2) to study the relationships between COP, central hemodynamics, and V?o2peak in HTRs and AMHCs.

METHODS: Twenty-six HTRs (3 women) and 27 AMHCs (5 women) were recruited. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamics (impedance cardiography), and left frontal COP (near-infrared spectroscopy) were measured continuously during and after a maximal ergocycle (Ergoline 800S, Bitz, Germany) test.

RESULTS: Compared with AMHCs, HTRs had lower V?o2peak, maximal cardiac index (CImax), and maximal ventilatory variables (P < 0.05). COP was lower during exercise (oxyhemoglobin [?O2Hb], 50% and 75% of V?O2peak, total hemoglobin [?tHb], 100% of V?O2peak; P < 0.05), and recovery in HTRs (?O2Hb, minutes 2-5; ?tHb, minutes 1-5; P < 0.05) compared with AMHCs. End-tidal pressure of CO2 was lower during exercise compared with that in AMHCs (P < 0.0001). In HTRs, CImax was positively correlated with exercise cerebral hemodynamics (R = 0.54-0.60; P < 0.01).

CONCLUSIONS: In HTRs, COP was reduced during exercise and recovery compared with that in AMHCs, potentially because of a combination of blunted cerebral vasodilation by CO2, cerebrovascular dysfunction, reduced cardiac function, and medication. The impaired V?O2peak observed in HTRs was mainly caused by reduced maximal ventilation and CI. In HTRs, COP is impaired and is correlated with cardiac function, potentially impacting cognitive function. Therefore, we need to study which interventions (eg, exercise training) are most effective for improving or normalizing (or both) COP during and after exercise in HTRs.

PMID: 26577897 [PubMed - indexed for MEDLINE]