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Drug discovery and chemical probing in Drosophila.

Author(s): Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Genome. 2020 Jun 18;: Authors: Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Article GUID: 32551911
Editorial: RNA Regulation in Development and Disease.

Author(s): Chartrand P, Jaramillo M, Gamberi C

Front Genet. 2020;11:430 Authors: Chartrand P, Jaramillo M, Gamberi C PMID: 32411184 [PubMed]

Article GUID: 32411184
Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics.

Author(s): Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Biomedicines. 2019 Oct 18;7(4): Authors: Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Article GUID: 31635379
Modeling Renal Disease "On the Fly".

Author(s): Millet-Boureima C, Porras Marroquin J, Gamberi C

Biomed Res Int. 2018;2018:5697436 Authors: Millet-Boureima C, Porras Marroquin J, Gamberi C

Article GUID: 29955604
Title:Drug discovery and chemical probing in Drosophila.
Authors:Millet-Boureima C,  Selber-Hnatiw S,  Gamberi C
Link:https://www.ncbi.nlm.nih.gov/pubmed/32551911?dopt=Abstract
DOI:10.1139/gen-2020-0037
Category:Genome
PMID:32551911
Dept Affiliation: BIOLOGY
1 Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada.

Description:

Drug discovery and chemical probing in Drosophila.

Genome. 2020 Jun 18;:

Authors: Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Abstract

Flies are increasingly utilized in drug discovery and chemical probing in vivo, which are novel technologies complementary to genetic probing in fundamental biological studies. Excellent genetic conservation, small size, short generation time and over one hundred years of genetics make Drosophila an attractive model for rapid assay readout and use of analytical amounts of compound, enabling the experimental iterations needed in early drug development at a fraction of time and costs. Here, we describe an effective drug-testing pipeline using adult flies that can be easily implemented to study several disease models and different genotypes to discover novel molecular insight, probes, quality lead compounds, and develop novel prototype drugs.

PMID: 32551911 [PubMed - as supplied by publisher]