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Drug discovery and chemical probing in Drosophila.

Author(s): Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Genome. 2020 Jun 18;: Authors: Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Article GUID: 32551911
Editorial: RNA Regulation in Development and Disease.

Author(s): Chartrand P, Jaramillo M, Gamberi C

Front Genet. 2020;11:430 Authors: Chartrand P, Jaramillo M, Gamberi C PMID: 32411184 [PubMed]

Article GUID: 32411184
Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics.

Author(s): Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Biomedicines. 2019 Oct 18;7(4): Authors: Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Article GUID: 31635379
Modeling Renal Disease "On the Fly".

Author(s): Millet-Boureima C, Porras Marroquin J, Gamberi C

Biomed Res Int. 2018;2018:5697436 Authors: Millet-Boureima C, Porras Marroquin J, Gamberi C

Article GUID: 29955604
Title:Modeling Renal Disease "On the Fly".
Authors:Millet-Boureima C,  Porras Marroquin J,  Gamberi C
Link:https://www.ncbi.nlm.nih.gov/pubmed/29955604?dopt=Abstract
DOI:10.1155/2018/5697436
Category:Biomed Res Int
PMID:29955604
Dept Affiliation: BIOLOGY
1 Biology Department, Concordia University, Montreal, QC, Canada.

Description:

Modeling Renal Disease "On the Fly".

Biomed Res Int. 2018;2018:5697436

Authors: Millet-Boureima C, Porras Marroquin J, Gamberi C

Abstract

Detoxification is a fundamental function for all living organisms that need to excrete catabolites and toxins to maintain homeostasis. Kidneys are major organs of detoxification that maintain water and electrolyte balance to preserve physiological functions of vertebrates. In insects, the renal function is carried out by Malpighian tubules and nephrocytes. Due to differences in their circulation, the renal systems of mammalians and insects differ in their functional modalities, yet carry out similar biochemical and physiological functions and share extensive genetic and molecular similarities. Evolutionary conservation can be leveraged to model specific aspects of the complex mammalian kidney function in the genetic powerhouse Drosophila melanogaster to study how genes interact in diseased states. Here, we compare the human and Drosophila renal systems and present selected fly disease models.

PMID: 29955604 [PubMed - indexed for MEDLINE]