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Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography.

Author(s): Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B...

OBJECTIVE: Fast Oscillations (FO) >40 Hz are a promising biomarker of the epileptogenic zone (EZ). Evidence using scalp electroencephalography (EEG) remains scarce. We assessed if electrical source...

Article GUID: 33450578
Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.

Author(s): Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Hum Brain Mapp. 2020 May 09;: Authors: Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Article GUID: 32386115
Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy.

Author(s): Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Brain Topogr. 2016 Jan;29(1):162-81 Authors: Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Article GUID: 25609211
MEG-EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy.

Author(s): Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Brain Topogr. 2015 Nov;28(6):785-812 Authors: Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Article GUID: 26016950
Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients.

Author(s): von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E

Brain Topogr. 2016 Mar;29(2):218-31 Authors: von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E

Article GUID: 26830767
Source localization of the seizure onset zone from ictal EEG/MEG data.

Author(s): Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2016 07;37(7):2528-46 Authors: Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 27059157
Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Author(s): Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Hum Brain Mapp. 2018 01;39(1):218-231 Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 29024165
Comparison of the spatial resolution of source imaging techniques in high-density EEG and MEG.

Author(s): Hedrich T, Pellegrino G, Kobayashi E, Lina JM, Grova C

Neuroimage. 2017 08 15;157:531-544 Authors: Hedrich T, Pellegrino G, Kobayashi E, Lina JM, Grova C

Article GUID: 28619655
Title:Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography.
Authors:Avigdor T,  Abdallah C,  von Ellenrieder N,  Hedrich T,  Rubino A,  Lo Russo G,  Bernhardt B,  Nobili L,  Grova C,  Frauscher B
Link:https://www.ncbi.nlm.nih.gov/pubmed/33450578
DOI:10.1016/j.clinph.2020.11.031
Category:Clin Neurophysiol
PMID:33450578
Dept Affiliation: PERFORM
1 Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Canada.
2 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Canada.
3 Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
4 Claudio Munari Epilepsy Center, Niguarda Hospital, Milan, Italy.
5 Department of Neuroscience (DINOGMI), University of Genoa, Italy; IRCCS, Child Neuropsychiatry Unit, Instituto Giannina Gaslini, Genoa, Italy.
6 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Canada; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Multimodal Functional Imaging Lab, PERFORM Centre, Department of Physics, Concordia University, Montreal, QC, Canada.
7 Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Department of Medicine, Queen's University, Kingston, ON, Canada. Electronic address: birgit.frauscher@mcgill.ca.

Description:

Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography.

Clin Neurophysiol. 2020 Dec 22; 132(2):568-580

Authors: Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B

Abstract

OBJECTIVE: Fast Oscillations (FO) >40 Hz are a promising biomarker of the epileptogenic zone (EZ). Evidence using scalp electroencephalography (EEG) remains scarce. We assessed if electrical source imaging of FO using 256-channel high-density EEG (HD-EEG) is useful for EZ identification.

METHODS: We analyzed HD-EEG recordings of 10 focal drug-resistant epilepsy patients with seizure-free postsurgical outcome. We marked FO candidate events at the time of epileptic spikes and verified them by screening for an isolated peak in the time-frequency plot. We performed electrical source imaging of spikes and FO within the Maximum Entropy of the Mean framework. Source localization maps were validated against the surgical cavity.

RESULTS: We identified FO in five out of 10 patients who had a superficial or intermediate deep generator. The maximum of the FO maps was localized inside the cavity in all patients (100%). Analysis with a reduced electrode coverage using the 10-10 and 10-20 system showed a decreased localization accuracy of 60% and 40% respectively.

CONCLUSIONS: FO recorded with HD-EEG localize the EZ. HD-EEG is better suited to detect and localize FO than conventional EEG approaches.

SIGNIFICANCE: This study acts as proof-of-concept that FO localization using 256-channel HD-EEG is a viable marker of the EZ.

PMID: 33450578 [PubMed - as supplied by publisher]