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Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

Author(s): Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of ...

Article GUID: 33455300
Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.

Author(s): Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG

Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. O...

Article GUID: 31820915
Title:Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.
Authors:Huang Y,  Moini Jazani A,  Howell EP,  Oh JK,  Moffitt MG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31820915
DOI:10.1021/acsami.9b17101
Category:ACS Appl Mater Interfaces
PMID:31820915
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry , University of Victoria , PO Box 1700 Stn CSC, Victoria , BC V8W 2Y2 Canada.
2 Department of Chemistry and Biochemistry , Concordia University , 7141 Sherbrooke St. West , Montreal , Quebec H4B 1R6 , Canada.

Description:

Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.

ACS Appl Mater Interfaces. 2020 Jan 08; 12(1):177-190

Authors: Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG

Abstract

Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. On-chip self-assembly within a two-phase microfluidic reactor forms various "DualM" polymer nanoparticles (PNPs), including cylinders and multicompartment vesicles, with sizes and morphologies that are tunable with manufacturing flow rate. Complex kinetically trapped intermediates between shear-dependent states provide the most detailed mechanism to date of microfluidic PNP formation in the presence of flow-variable high shear. Glutathione (GSH)-triggered changes in PNP size and internal structure depend strongly on the initial flow-directed size and internal structure. Upon incubation in GSH, flow-directed PNPs with smaller average sizes showed a faster hydrodynamic size increase (attributed to junction cleavage) and those with higher excess Gibbs free energy showed faster inner compartment growth (attributed to pendant cleavage). These results demonstrate that the combination of chemical control of the location of biologically responsive linkages with microfluidic shear processing offers promising routes for tunable "smart" polymeric nanomedicines.

PMID: 31820915 [PubMed - indexed for MEDLINE]