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Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

Author(s): Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of ...

Article GUID: 33455300
Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.

Author(s): Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG

Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. O...

Article GUID: 31820915
Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length.

Author(s): Huang Y, Yim OS, Lai PS, Yu R, Chew SH, Gwee X, Nyunt MSZ, Gao Q, Ng TP, Ebstein RP, Gouin JP

Psychoneuroendocrinology. 2019 May;103:180-187 Authors: Huang Y, Yim OS, Lai PS, Yu R, Chew SH, Gwee X, Nyunt MSZ, Gao Q, Ng TP, Ebstein RP, Gouin JP

Article GUID: 30708136
Title:Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length.
Authors:Huang Y,  Yim OS,  Lai PS,  Yu R,  Chew SH,  Gwee X,  Nyunt MSZ,  Gao Q,  Ng TP,  Ebstein RP,  Gouin JP
Link:https://www.ncbi.nlm.nih.gov/pubmed/30708136?dopt=Abstract
Category:Psychoneuroendocrinology
PMID:30708136
Dept Affiliation: PSYCHOLOGY
1 Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
2 Department of Paediatrics, National University of Singapore, Singapore.
3 Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore; Department of Psychology, National University of Singapore, Singapore.
4 Department of Economics, National University of Singapore, Singapore.
5 Gerontological Research Programme, Department of Psychological Medicine, National University of Singapore, Singapore.
6 Department of Psychology, National University of Singapore, Singapore; China Center for Behavior Economics and Finance, South Western University Finance Economics, (SWUFE), Chengdu, China. Electronic address: ebstein@swufe.edu.cn.
7 Department of Psychology, Concordia University, Montreal, Canada. Electronic address: jp.gouin@concordia.ca.

Description:

Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length.

Psychoneuroendocrinology. 2019 May;103:180-187

Authors: Huang Y, Yim OS, Lai PS, Yu R, Chew SH, Gwee X, Nyunt MSZ, Gao Q, Ng TP, Ebstein RP, Gouin JP

Abstract

In a rapidly greying world, the notion that some individuals maintain successful aging trajectories, viz. high physical, cognitive, emotional, and social functioning in older age, is increasingly germane. Biomarkers of such successful aging are increasingly sought. Leukocyte telomere length (LTL), an emerging yardstick of cellular aging that is influenced by but distinct from chronological age, may also be associated to successful aging. Furthermore, given that socio-economic status (SES) influences successful aging trajectories, socioeconomic status may also moderate the association between chronological age and LTL. The goals of this study are to examine 1) whether successful aging is associated with LTL; 2) whether successful aging accounts for age-related LTL and 3) whether SES moderates the effect of age on LTL. Singaporean Chinese (n?=?353) aged 65-80 completed a multidimensional assessment of successful aging and provided blood samples for LTL analysis. Results show that LTL negatively correlates with chronological age and positively correlates with successful aging. Successful aging mediates the association between chronological age and LTL. Moderated mediation analyses show that lower SES is associated with stronger negative associations of chronological age with successful aging and LTL. Moreover, the cognitive functioning dimension of successful aging is uniquely associated with LTL and its association with chronological age is moderated by SES. This study provides evidence that among older Singaporean Chinese with lower SES, declines in successful aging and in cognitive functioning are linked to age-related LTL shortening and hence to accelerated aging at the cellular level.

PMID: 30708136 [PubMed - in process]