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Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm.

Author(s): Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Psychoneuroendocrinology. 2020 Apr 21;117:104697 Authors: Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Article GUID: 32442863
Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Author(s): Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Front Neurosci. 2019;13:798 Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Article GUID: 31447629
Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.

Author(s): Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier...

J Neuroendocrinol. 2019 Apr;31(4):e12698 Authors: Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier P, Du...

Article GUID: 30776161
Sensitization of sexual behaviors in ovariectomized Long-Evans rats is induced by a subthreshold dose of estradiol benzoate and attenuated by repeated copulation.

Author(s): Jones SL, Pfaus JG

Horm Behav. 2014 Sep;66(4):655-62 Authors: Jones SL, Pfaus JG

Article GUID: 25251978
The inhibitory effects of corncob bedding on sexual behavior in the ovariectomized Long-Evans rat treated with estradiol benzoate are overcome by male cues.

Author(s): Jones SL, Antonie RA, Pfaus JG

Horm Behav. 2015 Jun;72:39-48 Authors: Jones SL, Antonie RA, Pfaus JG

Article GUID: 25960082
Repeated administration of estradiol promotes mechanisms of sexual excitation and inhibition: Glutamate signaling in the ventromedial hypothalamus attenuates excitation.

Author(s): Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Behav Brain Res. 2015 Sep 15;291:118-129 Authors: Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Article GUID: 26008158
Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.

Author(s): Jones SL, Cordeaux E, Germé K, Pfaus JG

Horm Behav. 2015 Jul;73:104-15 Authors: Jones SL, Cordeaux E, Germé K, Pfaus JG

Article GUID: 26163151
RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.

Author(s): Jones SL, Gardner Gregory J, Pfaus JG

Horm Behav. 2015 Sep;75:1-10 Authors: Jones SL, Gardner Gregory J, Pfaus JG

Article GUID: 26210062
Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat.

Author(s): Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Horm Behav. 2015 Sep;75:70-7 Authors: Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Article GUID: 26278846
Facilitation of sexual behavior in ovariectomized rats by estradiol and testosterone: A preclinical model of androgen effects on female sexual desire.

Author(s): Jones SL, Ismail N, Pfaus JG

Psychoneuroendocrinology. 2017 05;79:122-133 Authors: Jones SL, Ismail N, Pfaus JG

Article GUID: 28278441
Title:Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.
Authors:Jones SL,  Rosenbaum S,  Gardner Gregory J,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31447629?dopt=Abstract
DOI:10.3389/fnins.2019.00798
Category:Front Neurosci
PMID:31447629
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.

Description:

Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Front Neurosci. 2019;13:798

Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Abstract

Testosterone can be safely and effectively administered to estrogen-treated post-menopausal women experiencing hypoactive sexual desire. However, in the United States and Canada, although it is often administered off-label, testosterone co-administered with estradiol is not a federally approved treatment for sexual arousal/desire disorder, partly because its mechanism is poorly understood. One possible mechanism involves the aromatization of testosterone to estradiol. In an animal model, the administration of testosterone propionate (TP) given in combination with estradiol benzoate (EB) significantly increases sexually appetitive behaviors (i.e., solicitations and hops/darts) in ovariectomized (OVX) Long-Evans rats, compared to those treated with EB-alone. The goal of current study was to test whether blocking aromatization of testosterone to estradiol would disrupt the facilitation of sexual behaviors in OVX Long-Evans rats, and to determine group differences in Fos immunoreactivity within brain regions involved in sexual motivation and reward. Groups of sexually experienced OVX Long-Evans rats were treated with EB alone, EB+TP, or EB+TP and the aromatase inhibitor Fadrozole (EB+TP+FAD). Females treated with EB+TP+FAD displayed significantly more hops and darts, solicitations and lordosis magnitudes when compared to EB-alone females. Furthermore, TP, administered with or without FAD, induced the activation of Fos-immunoreactivity in brain areas implicated in sexual motivation and reward including the medial preoptic area, ventrolateral division of the ventromedial nucleus of the hypothalamus, the nucleus accumbens core, and the prefrontal cortex. These results suggest that aromatization may not be necessary for TP to enhance female sexual behavior and that EB+TP may act via androgenic pathways to increase the sensitivity of response to male-related cues, to induce female sexual desire.

PMID: 31447629 [PubMed]