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Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm.

Author(s): Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Psychoneuroendocrinology. 2020 Apr 21;117:104697 Authors: Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Article GUID: 32442863
Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Author(s): Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Front Neurosci. 2019;13:798 Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Article GUID: 31447629
Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.

Author(s): Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier...

J Neuroendocrinol. 2019 Apr;31(4):e12698 Authors: Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier P, Du...

Article GUID: 30776161
Sensitization of sexual behaviors in ovariectomized Long-Evans rats is induced by a subthreshold dose of estradiol benzoate and attenuated by repeated copulation.

Author(s): Jones SL, Pfaus JG

Horm Behav. 2014 Sep;66(4):655-62 Authors: Jones SL, Pfaus JG

Article GUID: 25251978
The inhibitory effects of corncob bedding on sexual behavior in the ovariectomized Long-Evans rat treated with estradiol benzoate are overcome by male cues.

Author(s): Jones SL, Antonie RA, Pfaus JG

Horm Behav. 2015 Jun;72:39-48 Authors: Jones SL, Antonie RA, Pfaus JG

Article GUID: 25960082
Repeated administration of estradiol promotes mechanisms of sexual excitation and inhibition: Glutamate signaling in the ventromedial hypothalamus attenuates excitation.

Author(s): Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Behav Brain Res. 2015 Sep 15;291:118-129 Authors: Jones SL, Farisello L, Mayer-Heft N, Pfaus JG

Article GUID: 26008158
Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.

Author(s): Jones SL, Cordeaux E, Germé K, Pfaus JG

Horm Behav. 2015 Jul;73:104-15 Authors: Jones SL, Cordeaux E, Germé K, Pfaus JG

Article GUID: 26163151
RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.

Author(s): Jones SL, Gardner Gregory J, Pfaus JG

Horm Behav. 2015 Sep;75:1-10 Authors: Jones SL, Gardner Gregory J, Pfaus JG

Article GUID: 26210062
Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat.

Author(s): Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Horm Behav. 2015 Sep;75:70-7 Authors: Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Article GUID: 26278846
Facilitation of sexual behavior in ovariectomized rats by estradiol and testosterone: A preclinical model of androgen effects on female sexual desire.

Author(s): Jones SL, Ismail N, Pfaus JG

Psychoneuroendocrinology. 2017 05;79:122-133 Authors: Jones SL, Ismail N, Pfaus JG

Article GUID: 28278441
Title:Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm.
Authors:Yong Ping E,  Laplante DP,  Elgbeili G,  Jones SL,  Brunet A,  King S
Link:https://www.ncbi.nlm.nih.gov/pubmed/32442863?dopt=Abstract
DOI:10.1016/j.psyneuen.2020.104697
Category:Psychoneuroendocrinology
PMID:32442863
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Douglas Mental Health University Institute, Verdun, QC, Canada.
3 Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada.
4 Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada. Electronic address: suzanne.king@mcgill.ca.

Description:

Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm.

Psychoneuroendocrinology. 2020 Apr 21;117:104697

Authors: Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Abstract

BACKGROUND: Prenatal stress has been associated with adverse outcomes in offspring, including elevated risk of psychopathology. Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis has been posited as a biological mechanism underlying such consequences. The present study aimed to examine whether dysregulation of the offspring HPA axis mediates the relationship between prenatal stress exposure and adolescent psychopathology.

METHODS: Five months after the Quebec ice storm of 1998, women who had been pregnant at the time of the storm completed questionnaires about their objective hardship and subjective distress from the disaster. A total of 45 of their children, exposed to the ice storm in utero, participated at 13 years of age. Adolescents completed the Trier Social Stress Test while providing salivary samples to measure circulating cortisol levels. Maternal report of adolescent behaviors was assessed with the Child Behavior Checklist.

RESULTS: Results from the study found that greater objective hardship was associated with elevated offspring cortisol reactivity at 13 years of age. Furthermore, greater subjective distress was associated with greater externalizing behaviors. While lower cortisol reactivity predicted greater externalizing behaviors, it did not mediate the association between maternal objective hardship or subjective distress and offspring externalizing or internalizing behaviors.

CONCLUSIONS: Findings suggest that objective hardship in pregnancy has long-term implications for offspring HPA axis functioning, which is also associated with externalizing behaviors. While dysregulation of the offspring HPA axis did not mediate the association between prenatal stress and offspring psychopathological symptoms, further research is warranted to investigate programming of alternative biological systems.

PMID: 32442863 [PubMed - as supplied by publisher]