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Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.

Author(s): Khoo SY, Sciascia JM, Brown A, Chaudhri N

Front Behav Neurosci. 2020;14:5 Authors: Khoo SY, Sciascia JM, Brown A, Chaudhri N

Article GUID: 32116588
Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats.

Author(s): Khoo SY, Correia V, Uhrig A

Lab Anim. 2020 Jan 10;:23677219894356 Authors: Khoo SY, Correia V, Uhrig A

Article GUID: 31924130
The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.

Author(s): Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

J Psychopharmacol. 2019 May 09;:269881119844180 Authors: Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

Article GUID: 31070082
Justifiability and Animal Research in Health: Can Democratisation Help Resolve Difficulties?

Author(s): Khoo SY

Animals (Basel). 2018 Feb 14;8(2): Authors: Khoo SY

Article GUID: 29443894
Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding.

Author(s): Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Neuropsychopharmacology. 2019 Feb 08;: Authors: Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Article GUID: 30758331
Title:Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats.
Authors:Khoo SY,  Correia V,  Uhrig A
Link:https://www.ncbi.nlm.nih.gov/pubmed/31924130?dopt=Abstract
DOI:10.1177/0023677219894356
Category:Lab Anim
PMID:31924130
Dept Affiliation: CSBN
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, 5618Concordia University, Montreal, Canada.

Description:

Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats.

Lab Anim. 2020 Jan 10;:23677219894356

Authors: Khoo SY, Correia V, Uhrig A

Abstract

Individual or singly-housing laboratory rats is common in many animal facilities, but has an adverse impact on the welfare of this social species. It has previously been shown that a small proportion of individually housed mice (~5%) engage in pathological overgrooming behaviour, but this has not been assessed in rats. We performed an observational study to determine the prevalence of overgrooming-related self-injury and whether providing nesting material enrichment throughout an animal's life would affect the prevalence or severity of overgrooming-related self-injury. Due to protocol differences between projects in our behavioural neuroscience lab, unenriched rats received a nylabone and a shelter (n?=?167), while baseline-enriched rats received a nylabone, shelter and shredded paper nesting material throughout experiments (n?=?238). Unenriched rats received nesting material enrichment after the onset of overgrooming-related self-injury. Over 18 months, rats were monitored by their experimenters on a daily basis (5-7 days/week over 2-3 months/project) and any cases of overgrooming-related self-injury were recorded. Replicating the findings of previous studies in mice, we observed 20 cases of overgrooming-related self-injury (~5%) with no difference in prevalence between rats on the basis of supplier, cage position, experimental procedure (behavioural only or involving surgical procedures), reinforcer (ethanol or sugar) or level of baseline-enrichment. While there was no difference in onset severity between rats that were unenriched at baseline and baseline-enriched rats, baseline-enriched rats had lower self-injury severity scores at one-, two- and four-week follow-ups. These results suggest that nesting material enrichment provided throughout an animal's life may reduce overgrooming-related self-injury.

PMID: 31924130 [PubMed - as supplied by publisher]