Keyword search (3,448 papers available)


Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.

Author(s): Khoo SY, Sciascia JM, Brown A, Chaudhri N

Front Behav Neurosci. 2020;14:5 Authors: Khoo SY, Sciascia JM, Brown A, Chaudhri N

Article GUID: 32116588
Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats.

Author(s): Khoo SY, Correia V, Uhrig A

Lab Anim. 2020 Jan 10;:23677219894356 Authors: Khoo SY, Correia V, Uhrig A

Article GUID: 31924130
The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.

Author(s): Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

J Psychopharmacol. 2019 May 09;:269881119844180 Authors: Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

Article GUID: 31070082
Justifiability and Animal Research in Health: Can Democratisation Help Resolve Difficulties?

Author(s): Khoo SY

Animals (Basel). 2018 Feb 14;8(2): Authors: Khoo SY

Article GUID: 29443894
Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding.

Author(s): Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Neuropsychopharmacology. 2019 Feb 08;: Authors: Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Article GUID: 30758331
Title:The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.
Authors:Khoo SY,  Sciascia JM,  Pettorelli A,  Maddux JN,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/31070082?dopt=Abstract
Category:J Psychopharmacol
PMID:31070082
Dept Affiliation: PSYCHOLOGY
1 1 Center for Studies in Behavioral Neurobiology/FRQS Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, QC, Canada.
2 2 Department of Psychology, Lake Forest College, Lake Forest, IL, USA.

Description:

The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.

J Psychopharmacol. 2019 May 09;:269881119844180

Authors: Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

Abstract

BACKGROUND: The prelimbic medial prefrontal cortex is implicated in promoting drug-seeking in relapse tests. However, drug-seeking behaviour is typically extinguished before a test and tests normally occur without drug delivery.

AIMS: We investigated the involvement of the prelimbic and the infralimbic cortex in responding elicited by a non-extinguished cue for alcohol that was presented without alcohol in an alcohol-associated context or a neutral context, and in responding to the same cue when it was paired with alcohol.

METHODS: Male, Long-Evans rats (220-240 g on arrival) were acclimated to 15% ethanol (v/v; 'alcohol') and then trained to associate a conditioned stimulus (10 s white noise; 15 trials/session) with alcohol delivery into a fluid port (0.2 mL/conditioned stimulus, 3 mL per session) for oral intake. Conditioning sessions occurred in a specific 'alcohol context' and were alternated daily with exposure to a second 'neutral' context that contained neither the conditioned stimulus nor alcohol.

RESULTS: At test, functional prelimbic cortex inactivation using baclofen/muscimol reduced fluid port entries elicited by a non-extinguished conditioned stimulus that was presented without alcohol, but had no subsequent impact on port entries when the conditioned stimulus was paired with alcohol. Similar results were obtained following infralimbic cortex inactivation; however, infralimbic cortex inactivation also non-specifically reduced port entries in the absence of alcohol.

CONCLUSIONS: These data indicate that the prelimbic and infralimbic cortex are involved in responding to cues for alcohol when alcohol delivery is omitted, but suggest that other brain regions are engaged in responding to such cues in the presence of alcohol.

PMID: 31070082 [PubMed - as supplied by publisher]