Keyword search (3,939 papers available)


Academic success across the transition from primary to secondary schooling among lower-income adolescents: understanding the effects of family resources and gender.

Author(s): Serbin LA, Stack DM, Kingdon D

J Youth Adolesc. 2013 Sep;42(9):1331-47 Authors: Serbin LA, Stack DM, Kingdon D

Article GUID: 23904002
A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: moderation by method and mental health.

Author(s): Cardoso C, Kingdon D, Ellenbogen MA

Psychoneuroendocrinology. 2014 Nov;49:161-70 Authors: Cardoso C, Kingdon D, Ellenbogen MA

Article GUID: 25086828
Title:A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: moderation by method and mental health.
Authors:Cardoso C,  Kingdon D,  Ellenbogen MA
Link:https://www.ncbi.nlm.nih.gov/pubmed/25086828?dopt=Abstract
Category:Psychoneuroendocrinology
PMID:25086828
Dept Affiliation: PSYCHOLOGY
1 Centre for Research in Human Development, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6. Electronic address: christophercardoso@gmail.com.
2 Centre for Research in Human Development, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6.

Description:

A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: moderation by method and mental health.

Psychoneuroendocrinology. 2014 Nov;49:161-70

Authors: Cardoso C, Kingdon D, Ellenbogen MA

Abstract

BACKGROUND: A large body of research has examined the acute effects of intranasal oxytocin administration on social cognition and stress-regulation. While progress has been made with respect to understanding the effect of oxytocin administration on social cognition in clinical populations (e.g. autism, schizophrenia), less is known about its impact on the functioning of the hypothalamic-pituitary-adrenal (HPA) axis among individuals with a mental disorder.

METHOD: We conducted a meta-analysis on the acute effect of intranasal oxytocin administration on the cortisol response to laboratory tasks. The search yielded eighteen studies employing a randomized, placebo-controlled design (k=18, N=675). Random-effects models and moderator analyses were performed using the metafor package for the statistical program R.

RESULTS: The overall effect size estimate was modest and not statistically significant (Hedges g=-0.151, p=0.11) with moderate heterogeneity in this effect across studies (I(2)=31%). Controlling for baseline differences in cortisol concentrations, moderation analyses revealed that this effect was larger in response to challenging laboratory tasks that produced a robust stimulation of the HPA-axis (Hedges g=-0.433, 95% CI[-0.841, -0.025]), and in clinical populations relative to healthy controls (Hedges g=-0.742, 95% CI[-1.405, -0.078]).

CONCLUSION: Overall, oxytocin administration showed greater attenuation of the cortisol response to laboratory tasks that strongly activated the HPA-axis, relative to tasks that did not. The effect was more robust among clinical populations, suggesting possible increased sensitivity to oxytocin among those with a clinical diagnosis and concomitant social difficulties. These data support the view that oxytocin may play an important role in HPA dysfunction associated with psychopathology.

PMID: 25086828 [PubMed - indexed for MEDLINE]