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Pain in Youth with Sickle Cell Disease: A Report from the Sickle Cell Clinical Research and Intervention Program.

Author(s): Alberts NM, Kang G, Li C, Richardson PA, Hodges J, Hankins JS, Klosky JL

OBJECTIVES: Pain is prevalent among youth with sickle cell disease (SCD). However, previous research has been limited by small sample sizes, and lacked examinations of developmental differences in pain - which are critical to minimizing the development of c...

Article GUID: 33093339
Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.

Author(s): Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Horm Behav. 2017 03;89:113-120 Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Article GUID: 28062232
Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.

Author(s): Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

ACS Appl Mater Interfaces. 2018 Feb 07;10(5):4910-4920 Authors: Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

Article GUID: 29336139
Title:Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.
Authors:Almey A,  Arena L,  Oliel J,  Shams WM,  Hafez N,  Mancinelli C,  Henning L,  Tsanev A,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/28062232?dopt=Abstract
DOI:10.1016/j.yhbeh.2016.12.010
Category:Horm Behav
PMID:28062232
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: anne.almey@gmail.com.
2 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada.
3 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: waqqas19@gmail.com.
4 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.

Horm Behav. 2017 03;89:113-120

Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Abstract

There are sex differences associated with schizophrenia, as women exhibit later onset of the disorder, less severe symptomatology, and better response to antipsychotic medications. Estrogens are thought to play a role in these sex differences; estrogens facilitate the effects of antipsychotic medications to reduce the positive symptoms of schizophrenia, but it remains unclear whether estrogens protect against the cognitive symptoms of this disorder. Amphetamine sensitization is used to model some symptoms of schizophrenia in rats, including cognitive deficits like excessive perseveration and slower reversal learning. In this experiment female rats were administered a sensitizing regimen of amphetamine to mimic these cognitive symptoms. They were ovariectomized and administered either low or high estradiol replacement as well as chronic administration of the antipsychotic haloperidol, and were assessed in tests of perseveration and reversal learning. Results of these experiments demonstrated that, in amphetamine-sensitized rats, estradiol alone does not affect perseveration or reversal learning. However, low estradiol facilitates a 0.25mg/day dose of haloperidol to reduce perseveration and improve reversal learning. Combined high estradiol and 0.25mg/day haloperidol has no effect on perseveration or reversal learning, but high estradiol facilitates the effects of 0.13mg/day haloperidol to reduce perseveration and improve reversal learning. Thus, in amphetamine-sensitized female rats, 0.25mg/day haloperidol only improved perseveration and reversal learning when estradiol was low, while 0.13mg/day haloperidol only improved these cognitive processes when estradiol was high. These findings suggest that estradiol facilitates the effects of haloperidol to improve perseveration and reversal learning in a dose-dependent manner.

PMID: 28062232 [PubMed - indexed for MEDLINE]