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Pain in Youth with Sickle Cell Disease: A Report from the Sickle Cell Clinical Research and Intervention Program.

Author(s): Alberts NM, Kang G, Li C, Richardson PA, Hodges J, Hankins JS, Klosky JL

OBJECTIVES: Pain is prevalent among youth with sickle cell disease (SCD). However, previous research has been limited by small sample sizes, and lacked examinations of developmental differences in pain - which are critical to minimizing the development of c...

Article GUID: 33093339
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Horm Behav. 2017 03;89:113-120 Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Article GUID: 28062232
Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.

Author(s): Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

ACS Appl Mater Interfaces. 2018 Feb 07;10(5):4910-4920 Authors: Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

Article GUID: 29336139
Title:Pain in Youth with Sickle Cell Disease: A Report from the Sickle Cell Clinical Research and Intervention Program.
Authors:Alberts NM,  Kang G,  Li C,  Richardson PA,  Hodges J,  Hankins JS,  Klosky JL
Link:https://www.ncbi.nlm.nih.gov/pubmed/33093339
DOI:10.1097/AJP.0000000000000889
Category:Clin J Pain
PMID:33093339
Dept Affiliation: PSYCHOLOGY
1 Departments of Psychology.
2 Department of Psychology, Concordia University, Montréal, QC, Canada.
3 Biostatistics.
4 Departments of Pediatric Psychology and Pediatric Pain and Palliative Medicine, Helen DeVos Children's Hospital, Grand Rapids.
5 Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, East Lansing, MI.
6 Hematology, St. Jude Children's Research Hospital, Memphis, TN.
7 Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta.
8 Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.

Description:

Pain in Youth with Sickle Cell Disease: A Report from the Sickle Cell Clinical Research and Intervention Program.

Clin J Pain. 2020 Oct 21; :

Authors: Alberts NM, Kang G, Li C, Richardson PA, Hodges J, Hankins JS, Klosky JL

Abstract

OBJECTIVES: Pain is prevalent among youth with sickle cell disease (SCD). However, previous research has been limited by small sample sizes, and lacked examinations of developmental differences in pain - which are critical to minimizing the development of chronic pain as youth transition into adulthood. The primary aim of the current study was to compare pain and pain interference across four developmental groups in a large sample of youth with SCD. The secondary aim was to identify risk factors for greater pain and pain interference.

METHODS: Utilizing a cross-sectional study design, the expression and predictors of pain and pain interference was compared across four developmental stages: toddlers/preschoolers (2-4¦y), school-aged children (5-7¦y), preadolescents (8-12¦y), and adolescents (13-18¦y). Participants included 386 youth with SCD and their caregivers.

RESULTS: Caregiver-reported pain and pain interference as well as youth-reported pain interference increased across developmental groups, and plateaued approaching adolescence (multivariate analyses of variance P =0.002 for pain and P<0.001 for pain interference). Elevated fatigue, anxiety, and perceived difficulties with pain management were the most robust predictors of higher youth and caregiver-reported pain (ßs ranging from 0.15 to 0.68; P < 0.001) and pain interference (ßs ranging from 0.18 to 0.64; P < 0.001).

DISCUSSION: Disease and treatment-related variables were not associated with pain. Self-reported pain was elevated in older versus younger developmental groups, and was largely linked to anxiety, fatigue, and perceptions of pain management, thus highlighting the modifiable nature of factors influencing pain among youth with SCD.

PMID: 33093339 [PubMed - as supplied by publisher]