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Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm.

Author(s): Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Psychoneuroendocrinology. 2020 Apr 21;117:104697 Authors: Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Article GUID: 32442863
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Br J Clin Psychol. 2018 Dec 12;: Authors: Aardema F, Wong SF, Audet JS, Melli G, Baraby LP

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Author(s): Beauchet O, Montembeault M, Barden JM, Szturm T, Bherer L, Liu-Ambrose T, Chester VL, Li K, Helbostad JL, Allali G, Canadian Gait Consortium

Exp Gerontol. 2019 Jul 15;122:116-122 Authors: Beauchet O, Montembeault M, Barden JM, Szturm T, Bherer L, Liu-Ambrose T, Chester VL, Li K, Helbostad JL, Allali G, Canadian Gait Consortium

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Anti-Dementia Drugs, Gait Performance and Mental Imagery of Gait: A Non-Randomized Open-Label Trial.

Author(s): Beauchet O, Barden J, Liu-Ambrose T, Chester VL, Annweiler C, Szturm T, Grenier S, Léonard G, Bherer L, Allali G, Canadian Gait Consortium

Drugs Aging. 2016 09;33(9):665-73 Authors: Beauchet O, Barden J, Liu-Ambrose T, Chester VL, Annweiler C, Szturm T, Grenier S, Léonard G, Bherer L, Allali G, Canadian Gait Consortium

Article GUID: 27568453
Association Between Falls and Brain Subvolumes: Results from a Cross-Sectional Analysis in Healthy Older Adults.

Author(s): Beauchet O, Launay CP, Barden J, Liu-Ambrose T, Chester VL, Szturm T, Grenier S, Léonard G, Bherer L, Annweiler C, Helbostad JL, Verghese J,...

Brain Topogr. 2017 03;30(2):272-280 Authors: Beauchet O, Launay CP, Barden J, Liu-Ambrose T, Chester VL, Szturm T, Grenier S, Léonard G, Bherer L, Annweiler C, Helbostad JL, Verghese J, Allal...

Article GUID: 27785698
Title:Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm.
Authors:Yong Ping E,  Laplante DP,  Elgbeili G,  Jones SL,  Brunet A,  King S
Link:https://www.ncbi.nlm.nih.gov/pubmed/32442863?dopt=Abstract
DOI:10.1016/j.psyneuen.2020.104697
Category:Psychoneuroendocrinology
PMID:32442863
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Douglas Mental Health University Institute, Verdun, QC, Canada.
3 Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada.
4 Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada. Electronic address: suzanne.king@mcgill.ca.

Description:

Disaster-related prenatal maternal stress predicts HPA reactivity and psychopathology in adolescent offspring: Project Ice Storm.

Psychoneuroendocrinology. 2020 Apr 21;117:104697

Authors: Yong Ping E, Laplante DP, Elgbeili G, Jones SL, Brunet A, King S

Abstract

BACKGROUND: Prenatal stress has been associated with adverse outcomes in offspring, including elevated risk of psychopathology. Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis has been posited as a biological mechanism underlying such consequences. The present study aimed to examine whether dysregulation of the offspring HPA axis mediates the relationship between prenatal stress exposure and adolescent psychopathology.

METHODS: Five months after the Quebec ice storm of 1998, women who had been pregnant at the time of the storm completed questionnaires about their objective hardship and subjective distress from the disaster. A total of 45 of their children, exposed to the ice storm in utero, participated at 13 years of age. Adolescents completed the Trier Social Stress Test while providing salivary samples to measure circulating cortisol levels. Maternal report of adolescent behaviors was assessed with the Child Behavior Checklist.

RESULTS: Results from the study found that greater objective hardship was associated with elevated offspring cortisol reactivity at 13 years of age. Furthermore, greater subjective distress was associated with greater externalizing behaviors. While lower cortisol reactivity predicted greater externalizing behaviors, it did not mediate the association between maternal objective hardship or subjective distress and offspring externalizing or internalizing behaviors.

CONCLUSIONS: Findings suggest that objective hardship in pregnancy has long-term implications for offspring HPA axis functioning, which is also associated with externalizing behaviors. While dysregulation of the offspring HPA axis did not mediate the association between prenatal stress and offspring psychopathological symptoms, further research is warranted to investigate programming of alternative biological systems.

PMID: 32442863 [PubMed - as supplied by publisher]