Keyword search (3,619 papers available)


Functional PVDF ultrafiltration membrane for Tetrabromobisphenol-A (TBBPA) removal with high water recovery.

Author(s): Chen X, Huang G, Li Y, An C, Feng R, Wu Y, Shen J

Water Res. 2020 May 18;181:115952 Authors: Chen X, Huang G, Li Y, An C, Feng R, Wu Y, Shen J

Article GUID: 32497754
Effect of dissolved oxygen on simultaneous removal of ammonia, nitrate and phosphorus via biological aerated filter with sulfur and pyrite as composite fillers.

Author(s): Li Y, Guo J, Li H, Song Y, Chen Z, Lu C, Han Y, Hou Y

Bioresour Technol. 2019 Oct 28;296:122340 Authors: Li Y, Guo J, Li H, Song Y, Chen Z, Lu C, Han Y, Hou Y

Article GUID: 31704601
Resting-state and Vocabulary Tasks Distinctively Inform On Age-Related Differences in the Functional Brain Connectome.

Author(s): Ferré P, Benhajali Y, Steffener J, Stern Y, Joanette Y, Bellec P

Resting-state and Vocabulary Tasks Distinctively Inform On Age-Related Differences in the Functional Brain Connectome.
Lang Cogn Neurosci. 2019;34(8):949-972
Authors: Ferré P, Benhajali Y, Steffener J, Stern Y, Joanette Y, Bellec P
Abstract
...

Article GUID: 31457069
Chemogenomic Profiling of the Fungal Pathogen Candida albicans.

Author(s): Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M

Antimicrob Agents Chemother. 2018 02;62(2): Authors: Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M

Article GUID: 29203491
Erratum for Chen et al., "Chemogenomic Profiling of the Fungal Pathogen Candida albicans".

Author(s): Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M...

Antimicrob Agents Chemother. 2018 04;62(4): Authors: Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M...

Article GUID: 29588354
A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections.

Author(s): Ferreira RB, Valdez Y, Coombes BK, Sad S, Gouw JW, Brown EM, Li Y, Grassl GA, Antunes LC, Gill N, Truong M, Scholz R, Reynolds LA, Krishnan ...

MBio. 2015 Sep 22;6(5):e01421-15 Authors: Ferreira RB, Valdez Y, Coombes BK, Sad S, Gouw JW, Brown EM, Li Y, Grassl GA, Antunes LC, Gill N, Truong M, Scholz R, Reynolds LA, Krishnan L, Zafer AA, S...

Article GUID: 26396246
MEG-EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy.

Author(s): Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Brain Topogr. 2015 Nov;28(6):785-812 Authors: Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Article GUID: 26016950
The role of change in self-criticism across young adulthood in explaining developmental outcomes and psychological wellbeing.

Author(s): Michaeli Y, Kalfon Hakhmigari M, Dickson DJ, Scharf M, Shulman S

J Pers. 2018 Sep 27;: Authors: Michaeli Y, Kalfon Hakhmigari M, Dickson DJ, Scharf M, Shulman S

Article GUID: 30260502
Intracellular Delivery of Colloidally Stable Core-Cross-Linked Triblock Copolymer Micelles with Glutathione-Responsive Enhanced Drug Release for Cancer Therapy.

Author(s): Biswas D, An SY, Li Y, Wang X, Oh JK

Mol Pharm. 2017 08 07;14(8):2518-2528 Authors: Biswas D, An SY, Li Y, Wang X, Oh JK

Article GUID: 28207270
Title:Chemogenomic Profiling of the Fungal Pathogen Candida albicans.
Authors:Chen Y,  Mallick J,  Maqnas A,  Sun Y,  Choudhury BI,  Côte P,  Yan L,  Ni TJ,  Li Y,  Zhang D,  Rodríguez-Ortiz R,  Lv QZ,  Jiang YY,  Whiteway M
Link:https://www.ncbi.nlm.nih.gov/pubmed/29203491?dopt=Abstract
DOI:10.1128/AAC.02365-17
Category:Antimicrob Agents Chemother
PMID:29203491
Dept Affiliation: BIOLOGY
1 Biology Department, Concordia University, Montreal, Canada.
2 Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
3 Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
4 CONACYT, Institute of Neurobiology, UNAM, Juriquilla Campus, Querétaro, Mexico.
5 Biology Department, Concordia University, Montreal, Canada malcolm.whiteway@concordia.ca.

Description:

Chemogenomic Profiling of the Fungal Pathogen Candida albicans.

Antimicrob Agents Chemother. 2018 02;62(2):

Authors: Chen Y, Mallick J, Maqnas A, Sun Y, Choudhury BI, Côte P, Yan L, Ni TJ, Li Y, Zhang D, Rodríguez-Ortiz R, Lv QZ, Jiang YY, Whiteway M

Abstract

There is currently a small number of classes of antifungal drugs, and these drugs are known to target a very limited set of cellular functions. We derived a set of approximately 900 nonessential, transactivator-defective disruption strains from the tetracycline-regulated GRACE collection of strains of the fungal pathogen Candida albicans This strain set was screened against classic antifungal drugs to identify gene inactivations that conferred either enhanced sensitivity or increased resistance to the compounds. We examined two azoles, fluconazole and posaconazole; two echinocandins, caspofungin and anidulafungin; and a polyene, amphotericin B. Overall, the chemogenomic profiles within drug classes were highly similar, but there was little overlap between classes, suggesting that the different drug classes interacted with discrete networks of genes in C. albicans We also tested two pyridine amides, designated GPI-LY7 and GPI-C107; these drugs gave very similar profiles that were distinct from those of the echinocandins, azoles, or polyenes, supporting the idea that they target a distinct cellular function. Intriguingly, in cases where these gene sets can be compared to genetic disruptions conferring drug sensitivity in other fungi, we find very little correspondence in genes. Thus, even though the drug targets are the same in the different species, the specific genetic profiles that can lead to drug sensitivity are distinct. This implies that chemogenomic screens of one organism may be poorly predictive of the profiles found in other organisms and that drug sensitivity and resistance profiles can differ significantly among organisms even when the apparent target of the drug is the same.

PMID: 29203491 [PubMed]