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Ageism and COVID-19: What does our society's response say about us?

Author(s): Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beauli...

Age Ageing. 2020 May 06;: Authors: Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beaulieu M, Berge...

Article GUID: 32377666
Effects of Dance/Movement Training vs. Aerobic Exercise Training on cognition, physical fitness and quality of life in older adults: A randomized controlled trial.

Author(s): Esmail A, Vrinceanu T, Lussier M, Predovan D, Berryman N, Houle J, Karelis A, Grenier S, Minh Vu TT, Villalpando JM, Bherer L

J Bodyw Mov Ther. 2020 Jan;24(1):212-220 Authors: Esmail A, Vrinceanu T, Lussier M, Predovan D, Berryman N, Houle J, Karelis A, Grenier S, Minh Vu TT, Villalpando JM, Bherer L

Article GUID: 31987547
SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment.

Author(s): Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais ...

BMC Geriatr. 2018 04 16;18(1):93 Authors: Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini...

Article GUID: 29661156
Switching Ability Mediates the Age-Related Difference in Timed Up and Go Performance.

Author(s): Langeard A, Houdeib R, Saillant K, Kaushal N, Lussier M, Bherer L

J Alzheimers Dis. 2019 Mar 18;: Authors: Langeard A, Houdeib R, Saillant K, Kaushal N, Lussier M, Bherer L

Article GUID: 30909238
Limited Benefits of Heterogeneous Dual-Task Training on Transfer Effects in Older Adults.

Author(s): Lussier M, Brouillard P, Bherer L

J Gerontol B Psychol Sci Soc Sci. 2017 Sep 01;72(5):801-812 Authors: Lussier M, Brouillard P, Bherer L

Article GUID: 26603017
Specific transfer effects following variable priority dual-task training in older adults.

Author(s): Lussier M, Bugaiska A, Bherer L

Restor Neurol Neurosci. 2017;35(2):237-250 Authors: Lussier M, Bugaiska A, Bherer L

Article GUID: 27372514
A comparison of the impact of physical exercise, cognitive training and combined intervention on spontaneous walking speed in older adults.

Author(s): Pothier K, Gagnon C, Fraser SA, Lussier M, Desjardins-Crépeau L, Berryman N, Kergoat MJ, Vu TTM, Li KZH, Bosquet L, Bherer L

Aging Clin Exp Res. 2018 Aug;30(8):921-925 Authors: Pothier K, Gagnon C, Fraser SA, Lussier M, Desjardins-Crépeau L, Berryman N, Kergoat MJ, Vu TTM, Li KZH, Bosquet L, Bherer L

Article GUID: 29235076
Title:SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment.
Authors:Montero-Odasso M,  Almeida QJ,  Burhan AM,  Camicioli R,  Doyon J,  Fraser S,  Li K,  Liu-Ambrose T,  Middleton L,  Muir-Hunter S,  McIlroy W,  Morais JA,  Pieruccini-Faria F,  Shoemaker K,  Speechley M,  Vasudev A,  Zou GY,  Berryman N,  Lussier M,  Vanderhaeghe L,  Bherer L
Link:https://www.ncbi.nlm.nih.gov/pubmed/29661156?dopt=Abstract
DOI:10.1186/s12877-018-0782-7
Category:BMC Geriatr
PMID:29661156
Dept Affiliation: PERFORM
1 Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada. mmontero@uwo.ca.
2 Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada. mmontero@uwo.ca.
3 Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, London, Canada. mmontero@uwo.ca.
4 Sun Life Financial Movement Disorders Research Centre, Wilfrid Laurier University, Waterloo, Canada.
5 Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
6 Geriatric and Cognitive Neurology, University of Alberta, Edmonton, Canada.
7 Functional Neuroimaging Unit, University of Montreal, Montreal, Canada.
8 Department of Psychology-University of Ottawa, Ottawa, Canada.
9 Department of Psychology and PERFORM Centre, Concordia University, Montreal, Canada.
10 Department of Physical Therapy, University of British Columbia, Centre for Hip Health and Mobility, and Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Research Institute, University of British Columbia, Vancouver, Canada.
11 Department of Kinesiology, University of Waterloo, Waterloo, Canada.
12 School of Physical Therapy, University of Western Ontario, London, Canada.
13 Division of Neurology and Department of Medicine, University of Toronto. Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.
14 Division of Geriatrics and Centre of Excellence in Aging and Chronic Disease, McGill University, Montreal, Canada.
15 Department of Medicine, Division of Geriatric Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
16 Gait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, London, Canada.
17 Department of Kinesiology, University of Western Ontario, London, Canada.
18 Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
19 Department of Psychiatry, Division of Geriatric Psychiatry and Department of Medicine, Division of Clinical Pharmacology, University of Western Ontario, London, Canada.
20 Robarts Clinical Trials Inc, London, Canada.
21 Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Canada.
22 Department of Sports Studies, Bishop's University, Sherbrooke, Canada.
23 Faculty of Medicine, University of Montreal, Montréal, Canada.
24 St. Joseph's Health Care, London, Canada.
25 Montreal Heart Institute, Research Centre, Montreal, Canada.

Description:

SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment.

BMC Geriatr. 2018 04 16;18(1):93

Authors: Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini-Faria F, Shoemaker K, Speechley M, Vasudev A, Zou GY, Berryman N, Lussier M, Vanderhaeghe L, Bherer L

Abstract

BACKGROUND: Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Aerobic and progressive resistance exercises have benefits to cognitive performance, though evidence is somewhat inconsistent. We postulate that combined aerobic exercise (AE) and progressive resistance training (RT) (combined exercise) will have a better effect on cognition than a balance and toning control (BAT) intervention in older adults with MCI. We also expect that adding cognitive training and vitamin D supplementation to the combined exercise, as a multimodal intervention, will have synergistic efficacy.

METHODS: The SYNERGIC trial (SYNchronizing Exercises, Remedies in GaIt and Cognition) is a multi-site, double-blinded, five-arm, controlled trial that assesses the potential synergic effect of combined AE and RT on cognition and mobility, with and without cognitive training and vitamin D supplementation in older adults with MCI. Two-hundred participants with MCI aged 60 to 85 years old will be randomized to one of five arms, four of which include combined exercise plus combinations of dual-task cognitive training (real vs. sham) and vitamin D supplementation (3?×?10,000 IU/wk. vs. placebo) in a quasi-factorial design, and one arm which receives all control interventions. The primary outcome measure is the ADAS-Cog (13 and plus modalities) measured at baseline and at 6 months of follow-up. Secondary outcomes include neuroimaging, neuro-cognitive performance, gait and mobility performance, and serum biomarkers of inflammation (C reactive protein and interleukin 6), neuroplasticity (brain-derived neurotropic factor), endothelial markers (vascular endothelial growth factor 1), and vitamin D serum levels.

DISCUSSION: The SYNERGIC Trial will establish the efficacy and feasibility of a multimodal intervention to improve cognitive performance and mobility outcomes in MCI. These interventions may contribute to new approaches to stabilize and reverse cognitive-mobility decline in older individuals with MCI.

TRIAL REGISTRATION: Identifier: NCT02808676. https://www.clinicaltrials.gov/ct2/show/NCT02808676 .

PMID: 29661156 [PubMed - indexed for MEDLINE]