Keyword search (3,448 papers available)


Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae.

Author(s): Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI

Front Biosci (Landmark Ed). 2018 Jan 01;23:1166-1194 Authors: Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI

Article GUID: 28930594
Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2018 Mar 15;19(3): Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29543708
Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Oxid Med Cell Longev. 2018;2018:3074769 Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29636840
Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.

Author(s): Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI

Oncotarget. 2019 Jan 08;10(3):313-338 Authors: Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI

Article GUID: 30719227
Title:Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.
Authors:Mohammad K,  Dakik P,  Medkour Y,  McAuley M,  Mitrofanova D,  Titorenko VI
Link:https://www.ncbi.nlm.nih.gov/pubmed/29636840?dopt=Abstract
DOI:10.1155/2018/3074769
Category:Oxid Med Cell Longev
PMID:29636840
Dept Affiliation: BIOLOGY
1 Concordia University, Department of Biology, Montreal, QC, Canada H4B 1R6.

Description:

Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

Oxid Med Cell Longev. 2018;2018:3074769

Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Abstract

A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular mechanisms through which impaired lipid metabolism causes lipotoxicity and elicits different forms of regulated cell death. Here, we discuss mechanisms of the "liponecrotic" mode of regulated cell death in S. cerevisiae. This mode of regulated cell death can be initiated in response to a brief treatment of yeast with exogenous palmitoleic acid. Such treatment prompts the incorporation of exogenously added palmitoleic acid into phospholipids and neutral lipids. This orchestrates a global remodeling of lipid metabolism and transfer in the endoplasmic reticulum, mitochondria, lipid droplets, and the plasma membrane. Certain features of such remodeling play essential roles either in committing yeast to liponecrosis or in executing this mode of regulated cell death. We also outline four processes through which yeast cells actively resist liponecrosis by adapting to the cellular stress imposed by palmitoleic acid and maintaining viability. These prosurvival cellular processes are confined in the endoplasmic reticulum, lipid droplets, peroxisomes, autophagosomes, vacuoles, and the cytosol.

PMID: 29636840 [PubMed - indexed for MEDLINE]