Keyword search (3,448 papers available)


Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

Author(s): Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of ...

Article GUID: 33455300
Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.

Author(s): Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG

Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. O...

Article GUID: 31820915
Direct Polymerization Approach to Synthesize Acid-Degradable Block Copolymers Bearing Imine Pendants for Tunable pH-Sensitivity and Enhanced Release.

Author(s): Hu X, Oh JK

The development of effective approaches to synthesize smart amphiphilic block copolymers (ABPs) exhibiting acid-responsive degradation through the cleavage of acid-labile imine bonds is extensively explored for controlled release of encapsulated biomolecule...

Article GUID: 32964550
Self-Healable Reprocessable Triboelectric Nanogenerators Fabricated with Vitrimeric Poly(hindered Urea) Networks.

Author(s): Patel T, Kim MP, Park J, Lee TH, Nellepalli P, Noh SM, Jung HW, Ko H, Oh JK

In recent years, the advent of highly deformable and healable electronics is exciting and promising for next-generation electronic devices. In particular, self-healable triboelectric nanogenerators (SH-TENGs) serve as promising candidates based on the combi...

Article GUID: 32840992
Dual Reduction/Acid-Responsive Disassembly and Thermoresponsive Tunability of Degradable Double Hydrophilic Block Copolymer.

Author(s): Maruya-Li K, Shetty C, Moini Jazani A, Arezi N, Oh JK

ACS Omega. 2020 Feb 25;5(7):3734-3742 Authors: Maruya-Li K, Shetty C, Moini Jazani A, Arezi N, Oh JK

Article GUID: 32118189
Facile Strategies to Synthesize Dual Location Dual Acidic pH/Reduction-Responsive Degradable Block Copolymers Bearing Acetal/Disulfide Block Junctions and Disulfide Pendants.

Author(s): Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK

ACS Omega. 2018 Aug 31;3(8):8980-8991 Authors: Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK

Article GUID: 31459031
Reduction-Responsive Sheddable Carbon Nanotubes Dispersed in Aqueous Solution.

Author(s): An SY, Sun S, Oh JK

Macromol Rapid Commun. 2016 Apr;37(8):705-10 Authors: An SY, Sun S, Oh JK

Article GUID: 26890479
Intracellular Delivery of Colloidally Stable Core-Cross-Linked Triblock Copolymer Micelles with Glutathione-Responsive Enhanced Drug Release for Cancer Therapy.

Author(s): Biswas D, An SY, Li Y, Wang X, Oh JK

Mol Pharm. 2017 08 07;14(8):2518-2528 Authors: Biswas D, An SY, Li Y, Wang X, Oh JK

Article GUID: 28207270
Multiblock Copolymer-Based Dual Dynamic Disulfide and Supramolecular Crosslinked Self-Healing Networks.

Author(s): An SY, Noh SM, Oh JK

Macromol Rapid Commun. 2017 Apr;38(8): Authors: An SY, Noh SM, Oh JK

Article GUID: 28221703
Enhancing targeted antibiotic therapy via pH responsive solid lipid nanoparticles from an acid cleavable lipid.

Author(s): Kalhapure RS, Sikwal DR, Rambharose S, Mocktar C, Singh S, Bester L, Oh JK, Renukuntla J, Govender T

Nanomedicine. 2017 Aug;13(6):2067-2077 Authors: Kalhapure RS, Sikwal DR, Rambharose S, Mocktar C, Singh S, Bester L, Oh JK, Renukuntla J, Govender T

Article GUID: 28434930
Stimulus-Responsive Degradable Polylactide-Based Block Copolymer Nanoassemblies for Controlled/Enhanced Drug Delivery.

Author(s): Bawa KK, Oh JK

Mol Pharm. 2017 08 07;14(8):2460-2474 Authors: Bawa KK, Oh JK

Article GUID: 28493712
Polymers in Drug Delivery: Chemistry and Applications.

Author(s): Oh JK

Mol Pharm. 2017 08 07;14(8):2459 Authors: Oh JK PMID: 28780874 [PubMed - indexed for MEDLINE]

Article GUID: 28780874
Thermally Labile Self-Healable Branched Gel Networks Fabricated by New Macromolecular Engineering Approach Utilizing Thermoreversibility.

Author(s): Jung S, Patel T, Oh JK

Macromol Rapid Commun. 2018 Mar;39(5): Authors: Jung S, Patel T, Oh JK

Article GUID: 29210490
Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.

Author(s): Hong SH, Patel T, Ip S, Garg S, Oh JK

Langmuir. 2018 03 13;34(10):3316-3325 Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK

Article GUID: 29485889
Dual disassembly and biological evaluation of enzyme/oxidation-responsive polyester-based nanoparticulates for tumor-targeting delivery.

Author(s): Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK

Colloids Surf B Biointerfaces. 2018 Dec 01;172:608-617 Authors: Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK

Article GUID: 30223243
PLA-Based Triblock Copolymer Micelles Exhibiting Dual Acidic pH/Reduction Responses at Dual Core and Core/Corona Interface Locations.

Author(s): Bawa KK, Jazani AM, Shetty C, Oh JK

Macromol Rapid Commun. 2018 Dec;39(24):e1800477 Authors: Bawa KK, Jazani AM, Shetty C, Oh JK

Article GUID: 30286258
Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment.

Author(s): Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D

ACS Nano. 2019 Jan 22;13(1):408-420 Authors: Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D

Article GUID: 30604607
Title:Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.
Authors:Huang Y,  Moini Jazani A,  Howell EP,  Oh JK,  Moffitt MG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31820915
DOI:10.1021/acsami.9b17101
Category:ACS Appl Mater Interfaces
PMID:31820915
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry , University of Victoria , PO Box 1700 Stn CSC, Victoria , BC V8W 2Y2 Canada.
2 Department of Chemistry and Biochemistry , Concordia University , 7141 Sherbrooke St. West , Montreal , Quebec H4B 1R6 , Canada.

Description:

Controlled Microfluidic Synthesis of Biological Stimuli-Responsive Polymer Nanoparticles.

ACS Appl Mater Interfaces. 2020 Jan 08; 12(1):177-190

Authors: Huang Y, Moini Jazani A, Howell EP, Oh JK, Moffitt MG

Abstract

Microfluidic flow-directed self-assembly of biological stimuli-responsive block copolymers is demonstrated with dual-location cleavable linkages at the junction between hydrophilic and hydrophobic blocks and on pendant group within the hydrophobic blocks. On-chip self-assembly within a two-phase microfluidic reactor forms various "DualM" polymer nanoparticles (PNPs), including cylinders and multicompartment vesicles, with sizes and morphologies that are tunable with manufacturing flow rate. Complex kinetically trapped intermediates between shear-dependent states provide the most detailed mechanism to date of microfluidic PNP formation in the presence of flow-variable high shear. Glutathione (GSH)-triggered changes in PNP size and internal structure depend strongly on the initial flow-directed size and internal structure. Upon incubation in GSH, flow-directed PNPs with smaller average sizes showed a faster hydrodynamic size increase (attributed to junction cleavage) and those with higher excess Gibbs free energy showed faster inner compartment growth (attributed to pendant cleavage). These results demonstrate that the combination of chemical control of the location of biologically responsive linkages with microfluidic shear processing offers promising routes for tunable "smart" polymeric nanomedicines.

PMID: 31820915 [PubMed - indexed for MEDLINE]