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Conditioning of Sexual Interests and Paraphilias in Humans Is Difficult to See, Virtually Impossible to Test, and Probably Exactly How It Happens: A Comment on Hsu and Bailey (2020).

Author(s): Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA

Arch Sex Behav. 2020 May 27;: Authors: Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA PMID: 32462414 [PubMed - as supplied by publisher]

Article GUID: 32462414
The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.

Author(s): Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Psychoneuroendocrinology. 2020 Feb 07;115:104606 Authors: Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Article GUID: 32087523
Correction to: Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2020 Jan 09;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31919562
Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits.

Author(s): Quintana GR, Mac Cionnaith CE, Pfaus JG

Proc Natl Acad Sci U S A. 2019 Dec 03;: Authors: Quintana GR, Mac Cionnaith CE, Pfaus JG PMID: 31796602 [PubMed - as supplied by publisher]

Article GUID: 31796602
Effect of CS preexposure on the conditioned ejaculatory preference of the male rat: behavioral analyses and neural correlates.

Author(s): Quintana GR, Jackson M, Nasr M, Pfaus JG

Learn Mem. 2018 10;25(10):513-521 Authors: Quintana GR, Jackson M, Nasr M, Pfaus JG

Article GUID: 30224554
First sexual experiences determine the development of conditioned ejaculatory preference in male rats.

Author(s): Quintana GR, Guizar A, Rassi S, Pfaus JG

Learn Mem. 2018 10;25(10):522-532 Authors: Quintana GR, Guizar A, Rassi S, Pfaus JG

Article GUID: 30224555
Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2019 Jul 29;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31359118
The whole versus the sum of some of the parts: toward resolving the apparent controversy of clitoral versus vaginal orgasms.

Author(s): Pfaus JG, Quintana GR, Mac Cionnaith C, Parada M

Socioaffect Neurosci Psychol. 2016;6:32578 Authors: Pfaus JG, Quintana GR, Mac Cionnaith C, Parada M

Article GUID: 27791968
Do rats have orgasms?

Author(s): Pfaus JG, Scardochio T, Parada M, Gerson C, Quintana GR, Coria-Avila GA

Socioaffect Neurosci Psychol. 2016;6:31883 Authors: Pfaus JG, Scardochio T, Parada M, Gerson C, Quintana GR, Coria-Avila GA

Article GUID: 27799081
Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat.

Author(s): Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Horm Behav. 2019 Mar;109:1-9 Authors: Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Article GUID: 30690029
Title:Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.
Authors:Quintana GR,  Birrel M,  Marceau S,  Kalantari N,  Bowden J,  Bachoura Y,  Borduas E,  Lemay V,  Payne JW,  Cionnaith CM,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/31359118?dopt=Abstract
DOI:10.1007/s00213-019-05334-9
Category:Psychopharmacology (Berl)
PMID:31359118
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, Canada.
2 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, Canada. jpfaus@uv.mx.
3 Centro de Investigaciones Cerebrales, Universidad Veracruzana, CP 91193, Xalapa, VER, Mexico. jpfaus@uv.mx.

Description:

Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Psychopharmacology (Berl). 2019 Jul 29;:

Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Abstract

RATIONALE: Male rats trained to associate a neutral odor or rodent jacket on a female with their post-ejaculatory reward state display a preference to ejaculate with females bearing the odor or jacket. This conditioned ejaculatory preference (CEP) can be shifted by systemic administration of the opioid antagonist naloxone (NAL) during training, such that NAL-trained males distribute their ejaculations to females without the cue, relative to saline (SAL)-trained males.

OBJECTIVE: The present study examined two brain sites, the medial preoptic area (mPOA) or ventral tegmental area (VTA), where the opioid reward state might be induced.

METHODS: Sexually naïve Long-Evans males were implanted with bilateral guide cannula aimed at either site before they underwent multi-ejaculatory conditioning trials at 4-day intervals with sexually receptive females that bore either an almond odor or rodent tethering jacket. Infusions of NAL (1 µl/side) or SAL (1 µl/side) were made prior to each conditioning trial. All males were infused with SAL prior to a final open-field choice test with two sexually receptive females, one scented and the other unscented, or one jacketed and the other unjacketed.

RESULTS: Males previously conditioned with SAL in either region showed significant CEP. In contrast, prior infusions of NAL to the mPOA shifted the preference towards the unfamiliar female, whereas prior infusions to the VTA abolished CEP for the odor. Subsequent detection of Fos protein induced by the cue showed that, relative to SAL-treated males, prior experience with NAL in the mPOA suppressed Fos in both the mPOA and VTA, whereas prior experience with NAL in to the VTA suppressed Fos in the VTA alone.

CONCLUSIONS: Opioid antagonism in the mPOA produces a state of non-reward whereas in the VTA, it produces a state in which the odor does not acquire incentive properties.

PMID: 31359118 [PubMed - as supplied by publisher]