Keyword search (3,448 papers available)


Conditioning of Sexual Interests and Paraphilias in Humans Is Difficult to See, Virtually Impossible to Test, and Probably Exactly How It Happens: A Comment on Hsu and Bailey (2020).

Author(s): Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA

Arch Sex Behav. 2020 May 27;: Authors: Pfaus JG, Quintana GR, Mac Cionnaith CE, Gerson CA, Dubé S, Coria-Avila GA PMID: 32462414 [PubMed - as supplied by publisher]

Article GUID: 32462414
The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.

Author(s): Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Psychoneuroendocrinology. 2020 Feb 07;115:104606 Authors: Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Article GUID: 32087523
Correction to: Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2020 Jan 09;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31919562
Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits.

Author(s): Quintana GR, Mac Cionnaith CE, Pfaus JG

Proc Natl Acad Sci U S A. 2019 Dec 03;: Authors: Quintana GR, Mac Cionnaith CE, Pfaus JG PMID: 31796602 [PubMed - as supplied by publisher]

Article GUID: 31796602
Effect of CS preexposure on the conditioned ejaculatory preference of the male rat: behavioral analyses and neural correlates.

Author(s): Quintana GR, Jackson M, Nasr M, Pfaus JG

Learn Mem. 2018 10;25(10):513-521 Authors: Quintana GR, Jackson M, Nasr M, Pfaus JG

Article GUID: 30224554
First sexual experiences determine the development of conditioned ejaculatory preference in male rats.

Author(s): Quintana GR, Guizar A, Rassi S, Pfaus JG

Learn Mem. 2018 10;25(10):522-532 Authors: Quintana GR, Guizar A, Rassi S, Pfaus JG

Article GUID: 30224555
Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2019 Jul 29;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31359118
The whole versus the sum of some of the parts: toward resolving the apparent controversy of clitoral versus vaginal orgasms.

Author(s): Pfaus JG, Quintana GR, Mac Cionnaith C, Parada M

Socioaffect Neurosci Psychol. 2016;6:32578 Authors: Pfaus JG, Quintana GR, Mac Cionnaith C, Parada M

Article GUID: 27791968
Do rats have orgasms?

Author(s): Pfaus JG, Scardochio T, Parada M, Gerson C, Quintana GR, Coria-Avila GA

Socioaffect Neurosci Psychol. 2016;6:31883 Authors: Pfaus JG, Scardochio T, Parada M, Gerson C, Quintana GR, Coria-Avila GA

Article GUID: 27799081
Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat.

Author(s): Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Horm Behav. 2019 Mar;109:1-9 Authors: Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Article GUID: 30690029
Title:The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.
Authors:Maseroli E,  Santangelo A,  Lara-Fontes B,  Quintana GR,  Mac Cionnaith CE,  Casarrubea M,  Ricca V,  Maggi M,  Vignozzi L,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/32087523?dopt=Abstract
DOI:10.1016/j.psyneuen.2020.104606
Category:Psychoneuroendocrinology
PMID:32087523
Dept Affiliation: PSYCHOLOGY
1 Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada.
2 Psychiatry Unit, Department of Health Sciences. University of Florence, Italy; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.). Human Physiology Section "Giuseppe Pagano", Corso Tukory 129, Palermo 90134, Italy.
3 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada; Centro De Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, VER 91193, Mexico.
4 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6 Canada.
5 Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.). Human Physiology Section "Giuseppe Pagano", Corso Tukory 129, Palermo 90134, Italy.
6 Psychiatry Unit, Department of Health Sciences. University of Florence, Italy.
7 Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; I.N.B.B., Biostructures and Biosystems National Institute, Viale Delle Medaglie d'Oro 305, Rome 00136, Italy.
8 Andrology, Women's Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence 50139, Italy; I.N.B.B., Biostructures and Biosystems National Institute, Viale Delle Medaglie d'Oro 305, Rome 00136, Italy. Electronic address: linda.vignozzi@unifi.it.

Description:

The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.

Psychoneuroendocrinology. 2020 Feb 07;115:104606

Authors: Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Abstract

It is still unclear whether Testosterone (T) increases sexual desire through a stimulation of the androgen receptor in relevant brain regions or through its conversion to estrogens. The aim of this study was to clarify the mechanisms of T facilitation of female sexual desire by assessing the effect of a non-aromatizable androgen (Dihydrotestosterone, DHT) in a validated animal model. Ovariectomized (OVX) Long-Evans rats were treated with oil (O) + O, 10 mcg Estradiol Benzoate (EB) + O, 10 mcg EB?+?500 mcg Progesterone (P), O?+?500 mcg DHT or 10 mcg EB?+?500 mcg DHT (n?=?12 per group). EB was administered 48?h, while P and DHT 4?h, prior to 4 sexual behavioral testing sessions in bisected unilevel pacing chambers. Appetitive behaviors (the frequencies of hops/darts and solicitations) were considered as the main outcome measure. Sexual receptivity indexes [lordosis magnitude, expressed as lordosis rating (LR), and lordosis quotient (LQ)], rejection responses, as well as mounts, intromissions and ejaculations received from the male were also coded. The probability of transition among sexual behaviors was evaluated by Transition Matrices; T-Pattern analysis was performed to detect hidden repeated temporal behavioral sequences. Preliminary analyses found no statistically significant differences between the O?+?O and EB?+?O groups, therefore we excluded the EB?+?O group from further analyses. Rats treated with EB?+?DHT displayed significantly more appetitive behaviors compared to negative controls (O?+?O and O?+?DHT), whereas no difference was observed between EB?+?DHT rats and positive controls (EB?+?P); noteworthy, a higher number of appetitive behaviors was observed in the O?+?DHT group compared to the O?+?O group. Furthermore, rats treated with EB?+?DHT showed significantly higher receptivity measures (LR and LQ) and received more mounts, intromissions and ejaculations compared to negative controls (O?+?O and O?+?DHT), to levels equivalent to EB?+?P. No differences were detected in female-male mounts or rejection responses among the 4 groups. Under a qualitative perspective, full solicitation was found exclusively in T-patterns of the EB?+?DHT group, which was also the only one to display T-patterns of higher order encompassing appetitive behaviors-only events. In conclusion, the administration of DHT in EB-primed OVX Long-Evans rats enhances sexual behavior measures. Specifically, DHT seems to stimulate sequences of appetitive behaviors separated from copulative/reproductive measures. Our data support an independent role of androgens in the facilitation of female sexual desire.

PMID: 32087523 [PubMed - as supplied by publisher]