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A novel homozygous variant in TRAPPC2L results in a neurodevelopmental disorder and disrupts TRAPP complex function.

Author(s): Al-Deri N, Okur V, Ahimaz P, Milev M, Valivullah Z, Hagen J, Sheng Y, Chung W, Sacher M, Ganapathi M...

BACKGROUND: Next-generation sequencing has facilitated the diagnosis of neurodevelopmental disorders with variable and non-specific clinical findings. Recently, a homozygous missense p.(Asp37Tyr) v...

Article GUID: 32843486
The contribution of dry indoor built environment on the spread of Coronavirus: Data from various Indian states.

Author(s): V AAR, R V, Haghighat F

Coronavirus spread is more serious in urban metropolitan cities compared to rural areas. It is observed from the data on the infection rate available in the various sources that the cold and dry conditions accelerate the spread of coronavirus. In the presen...

Article GUID: 32834934
Ageism and COVID-19: What does our society's response say about us?

Author(s): Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beauli...

Age Ageing. 2020 May 06;: Authors: Fraser S, Lagacé M, Bongué B, Ndeye N, Guyot J, Bechard L, Garcia L, Taler V, CCNA Social Inclusion and Stigma Working Group, Adam S, Beaulieu M, Berge...

Article GUID: 32377666
Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans.

Author(s): Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, Rodrigues F, Resendiz-Sharpe A, Lag...

mSphere. 2020 Apr 08;5(2): Authors: Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, Rodrigues F, Resendiz-Sharpe A, Lagrou K, Marcet-Houben...

Article GUID: 32269156
Enzymatic assay for GHB determination in forensic matrices.

Author(s): Grenier V, Huppé G, Lamarche M, Mireault P

J Anal Toxicol. 2012 Sep;36(7):523-8 Authors: Grenier V, Huppé G, Lamarche M, Mireault P

Article GUID: 22722059
Characterization and Efficient Management of Big Data in IoT-Driven Smart City Development.

Author(s): Alsaig A, Alagar V, Chammaa Z, Shiri N

Sensors (Basel). 2019 May 28;19(11): Authors: Alsaig A, Alagar V, Chammaa Z, Shiri N

Article GUID: 31141899
Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing.

Author(s): Sobol E, Baum O, Shekhter A, Wachsmann-Hogiu S, Shnirelman A, Alexandrovskaya Y, Sadovskyy I, Vinokur V

J Biomed Opt. 2017 09 01;22(9):91515 Authors: Sobol E, Baum O, Shekhter A, Wachsmann-Hogiu S, Shnirelman A, Alexandrovskaya Y, Sadovskyy I, Vinokur V

Article GUID: 28564689
Title:Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing.
Authors:Sobol E,  Baum O,  Shekhter A,  Wachsmann-Hogiu S,  Shnirelman A,  Alexandrovskaya Y,  Sadovskyy I,  Vinokur V
Link:https://www.ncbi.nlm.nih.gov/pubmed/28564689?dopt=Abstract
Category:J Biomed Opt
PMID:28564689
Dept Affiliation: PHYSICS
1 Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, RussiabFederal Scientific Research Centre "Crystallography and Photonics" of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia.
2 Federal Scientific Research Centre "Crystallography and Photonics" of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia.
3 Sechenov First Medical University of Moscow, Institute of Regenerative Medicine, Moscow, Russia.
4 University of California, Center for Biophotonics, Department of Pathology and Laboratory Medicine, Sacramento, California, United StateseMcGill University, Department of Bioengineering, Montreal, Canada.
5 Concordia University, Department of Mathematics and Statistics, Montreal, Canada.
6 Argonne National Laboratory, Materials Science Division, Argonne, Illinois, United States.

Description:

Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing.

J Biomed Opt. 2017 09 01;22(9):91515

Authors: Sobol E, Baum O, Shekhter A, Wachsmann-Hogiu S, Shnirelman A, Alexandrovskaya Y, Sadovskyy I, Vinokur V

Abstract

Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-and-error approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

PMID: 28564689 [PubMed - indexed for MEDLINE]