Keyword search (3,171 papers available)


Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults.

Author(s): Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

J Cereb Blood Flow Metab. 2019 Jul 25;:271678X19862873 Authors: Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

Article GUID: 31342831
Arterial stiffness and brain integrity: A review of MRI findings.

Author(s): Badji A, Sabra D, Bherer L, Cohen-Adad J, Girouard H, Gauthier CJ

Ageing Res Rev. 2019 May 04;53:100907 Authors: Badji A, Sabra D, Bherer L, Cohen-Adad J, Girouard H, Gauthier CJ

Article GUID: 31063866
Title:Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults.
Authors:Intzandt B,  Sabra D,  Foster C,  Desjardins-Crépeau L,  Hoge RD,  Steele CJ,  Bherer L,  Gauthier CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/31342831?dopt=Abstract
Category:J Cereb Blood Flow Metab
PMID:31342831
Dept Affiliation: PERFORM
1 INDI Department, Concordia University, Montreal, Canada.
2 PERFORM Centre, Concordia University, Montreal, Canada.
3 Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, Canada.
4 Départment de Médecine, Université de Montréal, Canada.
5 Physics Department, Concordia University, Montreal, Canada.
6 Centre de Recherche de l'Institut de Cardiologie de Montréal, Montréal, Canada.
7 Department of Neurology and Neurosurgery, McGill University, Canada.
8 Department of Psychology, Concordia University, Montreal, Canada.
9 Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Description:

Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults.

J Cereb Blood Flow Metab. 2019 Jul 25;:271678X19862873

Authors: Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

Abstract

Aging is accompanied by vascular and structural changes in the brain, which include decreased grey matter volume (GMV), cerebral blood flow (CBF), and cerebrovascular reactivity (CVR). Enhanced fitness in aging has been related to preservation of GMV and CBF, and in some cases CVR, although there are contradictory relationships reported between CVR and fitness. To gain a better understanding of the complex interplay between fitness and GMV, CBF and CVR, the present study assessed these factors concurrently. Data from 50 participants, aged 55 to 72, were used to derive GMV, CBF, CVR and VO2peak. Results revealed that lower CVR was associated with higher VO2peak throughout large areas of the cerebral cortex. Within these regions lower fitness was associated with higher CBF and a faster hemodynamic response to hypercapnia. Overall, our results indicate that the relationships between age, fitness, cerebral health and cerebral hemodynamics are complex, likely involving changes in chemosensitivity and autoregulation in addition to changes in arterial stiffness. Future studies should collect other physiological outcomes in parallel with quantitative imaging, such as measures of chemosensitivity and autoregulation, to further understand the intricate effects of fitness on the aging brain, and how this may bias quantitative measures of cerebral health.

PMID: 31342831 [PubMed - as supplied by publisher]