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Four-week prehabilitation program is sufficient to modify exercise behaviors and improve preoperative functional walking capacity in patients with colorectal cancer.

Author(s): Chen BP, Awasthi R, Sweet SN, Minnella EM, Bergdahl A, Santa Mina D, Carli F, Scheede-Bergdahl C

Support Care Cancer. 2017 01;25(1):33-40 Authors: Chen BP, Awasthi R, Sweet SN, Minnella EM, Bergdahl A, Santa Mina D, Carli F, Scheede-Bergdahl C

Article GUID: 27539131
Adaptation of mitochondrial expression and ATP production in dedifferentiating vascular smooth muscle cells.

Author(s): Scheede-Bergdahl C, Bergdahl A

Can J Physiol Pharmacol. 2017 Dec;95(12):1473-1479 Authors: Scheede-Bergdahl C, Bergdahl A

Article GUID: 28846852
Evaluation of supervised multimodal prehabilitation programme in cancer patients undergoing colorectal resection: a randomized control trial.

Author(s): Bousquet-Dion G, Awasthi R, Loiselle SÈ, Minnella EM, Agnihotram RV, Bergdahl A, Carli F, Scheede-Bergdahl C

Acta Oncol. 2018 Jun;57(6):849-859 Authors: Bousquet-Dion G, Awasthi R, Loiselle SÈ, Minnella EM, Agnihotram RV, Bergdahl A, Carli F, Scheede-Bergdahl C

Article GUID: 29327644
Maximizing patient adherence to prehabilitation: what do the patients say?

Author(s): Ferreira V, Agnihotram RV, Bergdahl A, van Rooijen SJ, Awasthi R, Carli F, Scheede-Bergdahl C

Support Care Cancer. 2018 Aug;26(8):2717-2723 Authors: Ferreira V, Agnihotram RV, Bergdahl A, van Rooijen SJ, Awasthi R, Carli F, Scheede-Bergdahl C

Article GUID: 29478189
Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice.

Author(s): Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A

J Physiol Biochem. 2019 Feb;75(1):65-72 Authors: Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A

Article GUID: 30362048
Title:Evaluation of supervised multimodal prehabilitation programme in cancer patients undergoing colorectal resection: a randomized control trial.
Authors:Bousquet-Dion G,  Awasthi R,  Loiselle SÈ,  Minnella EM,  Agnihotram RV,  Bergdahl A,  Carli F,  Scheede-Bergdahl C
Link:https://www.ncbi.nlm.nih.gov/pubmed/29327644?dopt=Abstract
Category:Acta Oncol
PMID:29327644
Dept Affiliation: HKAP
1 a Department of Anesthesia , McGill University Health Center , Montreal , Canada.
2 b School of Anesthesia and Intensive Care , University of Milan , Milan , Italy.
3 c Research Institute-McGill University Health Center , Montreal , Canada.
4 d Department of Exercise Science , Concordia University , Montreal , Canada.
5 e Department of Kinesiology and Physical Education , McGill University , Montreal , Canada.
6 f McGill Research Centre for Physical Activity & Health, McGill University , Montreal , Canada.

Description:

Evaluation of supervised multimodal prehabilitation programme in cancer patients undergoing colorectal resection: a randomized control trial.

Acta Oncol. 2018 Jun;57(6):849-859

Authors: Bousquet-Dion G, Awasthi R, Loiselle SÈ, Minnella EM, Agnihotram RV, Bergdahl A, Carli F, Scheede-Bergdahl C

Abstract

BACKGROUND: Prehabilitation has been previously shown to be more effective in enhancing postoperative functional capacity than rehabilitation alone. The purpose of this study was to determine whether a weekly supervised exercise session could provide further benefit to our current prehabilition program, when comparing to standard post-surgical rehabilitation.

METHODS: A parallel-arm single-blind randomized control trial was conducted in patients scheduled for non-metastatic colorectal cancer resection. Patients were assigned to either a once weekly supervised prehabilitation (PREHAB+, n?=?41) or standard rehabilitation (REHAB, n?=?39) program. Both multimodal programs were home-based program and consisted of moderate intensity aerobic and resistance exercise, nutrition counseling with daily whey protein supplementation and anxiety-reduction strategies. Perioperative care was standardized for both groups as per enhanced recovery after surgery (ERAS®) guidelines. Functional exercise capacity, as determined by the 6-minute walk test distance (6MWD), was the primary outcome. Exercise quantity, intensity and energy expenditure was determined by the CHAMPS questionnaire.

RESULTS: Both groups were comparable for baseline walking capacity (PREHAB+: 448 m [IQR 375-525] vs. REHAB: 461 m [419-556], p=.775) and included a similar proportion of patients who improved walking capacity (>20 m) during the preoperative period (PREHAB+: 54% vs. REHAB: 38%, p?=?.222). After surgery, changes in 6MWD were also similar in both groups. In PREHAB+, however, there was a significant association between physical activity energy expenditure and 6MWD (p?<?.01). Previously inactive patients were more likely to improve functional capacity due to PREHAB+ (OR 7.07 [95% CI 1.10-45.51]).

CONCLUSIONS: The addition of a weekly supervised exercise session to our current prehabilitation program did not further enhance postoperative walking capacity when compared to standard REHAB care. Sedentary patients, however, seemed more likely to benefit from PREHAB+. An association was found between energy spent in physical activity and 6MWD. This information is important to consider when designing cost-effective prehabilitation programs.

PMID: 29327644 [PubMed - indexed for MEDLINE]