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Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward.

Author(s): Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P

PLoS One. 2020;15(6):e0226722 Authors: Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P

Article GUID: 32502210
The priming effect of food persists following blockade of dopamine receptors.

Author(s): Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich ...

Eur J Neurosci. 2019 Jul 27;: Authors: Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumro...

Article GUID: 31350860
Learning to use past evidence in a sophisticated world model.

Author(s): Ahilan S, Solomon RB, Breton YA, Conover K, Niyogi RK, Shizgal P, Dayan P

PLoS Comput Biol. 2019 Jun 24;15(6):e1007093 Authors: Ahilan S, Solomon RB, Breton YA, Conover K, Niyogi RK, Shizgal P, Dayan P

Article GUID: 31233559
Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation.

Author(s): Hernandez G, Cossette MP, Shizgal P, Rompré PP

Front Behav Neurosci. 2016;10:161 Authors: Hernandez G, Cossette MP, Shizgal P, Rompré PP

Article GUID: 27616984
Valuation of opportunity costs by rats working for rewarding electrical brain stimulation.

Author(s): Solomon RB, Conover K, Shizgal P

PLoS One. 2017;12(8):e0182120 Authors: Solomon RB, Conover K, Shizgal P

Article GUID: 28841663
17β-estradiol locally increases phasic dopamine release in the dorsal striatum.

Author(s): Shams WM, Cossette MP, Shizgal P, Brake WG

Neurosci Lett. 2018 02 05;665:29-32 Authors: Shams WM, Cossette MP, Shizgal P, Brake WG

Article GUID: 29175028
Some work and some play: microscopic and macroscopic approaches to labor and leisure.

Author(s): Niyogi RK, Shizgal P, Dayan P

PLoS Comput Biol. 2014 Dec;10(12):e1003894 Authors: Niyogi RK, Shizgal P, Dayan P

Article GUID: 25474151
Robust optical fiber patch-cords for in vivo optogenetic experiments in rats.

Author(s): Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

MethodsX. 2015;2:263-71 Authors: Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

Article GUID: 26150997
The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses.

Author(s): Cossette MP, Conover K, Shizgal P

Behav Brain Res. 2016 Jan 15;297:345-58 Authors: Cossette MP, Conover K, Shizgal P

Article GUID: 26477378
The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.

Author(s): Scardochio T, Trujillo-Pisanty I, Conover K, Shizgal P, Clarke PB

Front Behav Neurosci. 2015;9:331 Authors: Scardochio T, Trujillo-Pisanty I, Conover K, Shizgal P, Clarke PB

Article GUID: 26696851
Title:17β-estradiol locally increases phasic dopamine release in the dorsal striatum.
Authors:Shams WM,  Cossette MP,  Shizgal P,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/29175028?dopt=Abstract
DOI:10.1016/j.neulet.2017.11.039
Category:Neurosci Lett
PMID:29175028
Dept Affiliation: CSBN
1 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: waqqas.shams@gmail.com.
2 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: mpy_cossette@hotmail.com.
3 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: peter.shizgal@concordia.ca.
4 Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

17ß-estradiol locally increases phasic dopamine release in the dorsal striatum.

Neurosci Lett. 2018 02 05;665:29-32

Authors: Shams WM, Cossette MP, Shizgal P, Brake WG

Abstract

Studies using in vivo microdialysis have shown that 17ß-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anesthetized (1.5mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum. Rats were ovariectomized and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of~20-25pg/mL. DA release was evoked every 1min by delivering biphasic electrical stimulation in the substantia nigra. Local infusions of E2 (244.8pg/µl) into the dorsal striatum increased the amplitude of the electrically evoked DA transients. Behaviorally significant stimuli and events trigger phasic release of DA. The present findings predict that E2 would boost such signaling in behaving subjects.

PMID: 29175028 [PubMed - indexed for MEDLINE]