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Resting-state and Vocabulary Tasks Distinctively Inform On Age-Related Differences in the Functional Brain Connectome.

Author(s): Ferré P, Benhajali Y, Steffener J, Stern Y, Joanette Y, Bellec P

Resting-state and Vocabulary Tasks Distinctively Inform On Age-Related Differences in the Functional Brain Connectome.
Lang Cogn Neurosci. 2019;34(8):949-972
Authors: Ferré P, Benhajali Y, Steffener J, Stern Y, Joanette Y, Bellec P
Abstract
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Article GUID: 31457069
Differences between chronological and brain age are related to education and self-reported physical activity.

Author(s): Steffener J, Habeck C, O'Shea D, Razlighi Q, Bherer L, Stern Y

Neurobiol Aging. 2016 Apr;40:138-144 Authors: Steffener J, Habeck C, O'Shea D, Razlighi Q, Bherer L, Stern Y

Article GUID: 26973113
Title:Differences between chronological and brain age are related to education and self-reported physical activity.
Authors:Steffener J,  Habeck C,  O'Shea D,  Razlighi Q,  Bherer L,  Stern Y
Link:https://www.ncbi.nlm.nih.gov/pubmed/26973113?dopt=Abstract
DOI:10.1016/j.neurobiolaging.2016.01.014
Category:Neurobiol Aging
PMID:26973113
Dept Affiliation: PERFORM
1 PERFORM Centre, Concordia University, Montreal, Québec, Canada; Centre de Recherche de l'Institut de Gériatrie de Montréal, Montréal, Québec, Canada; Department of Psychology, Concordia University, Montreal, Québec, Canada. Electronic address: jason.steffener@concordia.ca.
2 Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA.
3 Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
4 PERFORM Centre, Concordia University, Montreal, Québec, Canada; Centre de Recherche de l'Institut de Gériatrie de Montréal, Montréal, Québec, Canada; Department of Psychology, Concordia University, Montreal, Québec, Canada.

Description:

Differences between chronological and brain age are related to education and self-reported physical activity.

Neurobiol Aging. 2016 Apr;40:138-144

Authors: Steffener J, Habeck C, O'Shea D, Razlighi Q, Bherer L, Stern Y

Abstract

This study investigated the relationship between education and physical activity and the difference between a physiological prediction of age and chronological age (CA). Cortical and subcortical gray matter regional volumes were calculated from 331 healthy adults (range: 19-79 years). Multivariate analyses identified a covariance pattern of brain volumes best predicting CA (R(2) = 47%). Individual expression of this brain pattern served as a physiologic measure of brain age (BA). The difference between CA and BA was predicted by education and self-report measures of physical activity. Education and the daily number of flights of stairs climbed (FOSC) were the only 2 significant predictors of decreased BA. Effect sizes demonstrated that BA decreased by 0.95 years for each year of education and by 0.58 years for 1 additional FOSC daily. Effects of education and FOSC on regional brain volume were largely driven by temporal and subcortical volumes. These results demonstrate that higher levels of education and daily FOSC are related to larger brain volume than predicted by CA which supports the utility of regional gray matter volume as a biomarker of healthy brain aging.

PMID: 26973113 [PubMed - indexed for MEDLINE]