Keyword search (3,447 papers available)


DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

Author(s): Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

J Affect Disord. 2020 Jun 15;271:160-168 Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Article GUID: 32479312
Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates.

Author(s): Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L

Psychoneuroendocrinology. 2018 11;97:196-205 Authors: Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L

Article GUID: 30059826
Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.

Author(s): Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Hum Brain Mapp. 2017 04;38(4):2037-2050 Authors: Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Article GUID: 28032437
Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Author(s): Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Eur Neuropsychopharmacol. 2017 10;27(10):1032-1041 Authors: Ismaylova E, Di Sante J, Szyf M, Nemoda Z, Yu WJ, Pomares FB, Turecki G, Gobbi G, Vitaro F, Tremblay RE, Booij L

Article GUID: 28774705
Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.

Author(s): Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Neuropsychopharmacology. 2018 04;43(5):1138-1145 Authors: Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Article GUID: 29182159
Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.

Author(s): Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Transl Psychiatry. 2018 08 08;8(1):147 Authors: Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Article GUID: 30089832
A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

Author(s): Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

J Psychiatry Neurosci. 2019 05 01;44(3):205-213 Authors: Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

Article GUID: 30693739
DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse.

Author(s): Farrell C, Doolin K, O' Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z, Szyf M, Booij L, O'Keane V

Psychiatry Res. 2018 07;265:341-348 Authors: Farrell C, Doolin K, O' Leary N, Jairaj C, Roddy D, Tozzi L, Morris D, Harkin A, Frodl T, Nemoda Z, Szyf M, Booij L, O'Keane V

Article GUID: 29793048
Title:Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates.
Authors:Di Sante J,  Ismaylova E,  Nemoda Z,  Gouin JP,  Yu WJ,  Caldwell W,  Vitaro F,  Szyf M,  Tremblay RE,  Booij L
Link:https://www.ncbi.nlm.nih.gov/pubmed/30059826?dopt=Abstract
DOI:10.1016/j.psyneuen.2018.07.019
Category:Psychoneuroendocrinology
PMID:30059826
Dept Affiliation: PSYCHOLOGY
1 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada.
2 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.
3 Department of Psychology, Concordia University, Montreal, Canada.
4 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
5 CHU Sainte-Justine Research Centre, Montreal, Canada; School of Psychoeducation, University of Montreal, Montreal, Canada.
6 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
7 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychology and Pediatrics, University of Montreal, Montreal, Canada; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland.
8 CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada. Electronic address: linda.booij@concordia.ca.

Description:

Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates.

Psychoneuroendocrinology. 2018 11;97:196-205

Authors: Di Sante J, Ismaylova E, Nemoda Z, Gouin JP, Yu WJ, Caldwell W, Vitaro F, Szyf M, Tremblay RE, Booij L

Abstract

Environmental factors can influence gene expression via epigenetic modifications such as DNA methylation. DNA methylation levels of regulatory regions in Hypothalamo-Pituitary-Adrenal (HPA) axis-related genes assessed from brain tissues as well as from surrogate, peripheral tissues have been associated with vulnerability to stress-related psychopathologies. Commonly used peripheral samples to assess DNA methylation in living humans are derived from blood, saliva or buccal cells. Although psychiatric epigenetic studies are increasingly relying on peripheral measures of DNA methylation, it is still unknown to what extent methylation patterns across peripheral tissues are associated with each other and with measures of brain processes and behavioural stress. In the present study, with a sample of 51 healthy adults, we assessed cross-tissue correlations of DNA methylation patterns in the glucocorticoid receptor (NR3C1) 1?F promoter and the FK506 Binding Protein 5 (FKBP5) gene intron 7 region using saliva and buccal cell samples, and assessed two-year stability in both tissues in a male subsample (N?=?14). We also investigated associations between peripherally-derived DNA methylation and measures of neural function and perceived daily stress, and compared the extent of these associations across tissue samples. DNA methylation cross-tissue correlations were highly significant for FKBP5, but not significant for NR3C1. DNA methylation in both genes remained stable for two years. Tissue- and gene-specific associations were found for brain resting state connectivity and neural responses to sadness, thereby suggesting that saliva- and buccal cell-derived DNA methylation levels of NR3C1-1?F and FKBP5 gene regions might differently capture different measures of putatively related brain processes. It was also found that greater buccal cell- (but not saliva-) derived NR3C1-1?F methylation was associated with lower perceived daily life demands. Results of the present study may inform the design of future epigenetic studies on FKBP5-intron-7 and NR3C1-1?F-promoter methylation in relation to neuro-imaging and behavioural measures, and provide insight for the development of peripheral DNA methylation correlates of stress sensitivity and resilience.

PMID: 30059826 [PubMed - indexed for MEDLINE]