PERFORM Publications

Title:	Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing.
Authors:	Sobol E , Baum O , Shekhter A , Wachsmann-Hogiu S , Shnirelman A , Alexandrovskaya Y , Sadovskyy I , Vinokur V
Link:	https://www.ncbi.nlm.nih.gov/pubmed/28564689?dopt=Abstract
Category:	J Biomed Opt
PMID:	28564689
Dept Affiliation:	PHYSICS 1 Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, RussiabFederal Scientific Research Centre "Crystallography and Photonics" of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia. 2 Federal Scientific Research Centre "Crystallography and Photonics" of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia. 3 Sechenov First Medical University of Moscow, Institute of Regenerative Medicine, Moscow, Russia. 4 University of California, Center for Biophotonics, Department of Pathology and Laboratory Medicine, Sacramento, California, United StateseMcGill University, Department of Bioengineering, Montreal, Canada. 5 Concordia University, Department of Mathematics and Statistics, Montreal, Canada. 6 Argonne National Laboratory, Materials Science Division, Argonne, Illinois, United States.

Description:

Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing.

J Biomed Opt. 2017 09 01;22(9):91515

Authors: Sobol E, Baum O, Shekhter A, Wachsmann-Hogiu S, Shnirelman A, Alexandrovskaya Y, Sadovskyy I, Vinokur V

Abstract

Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-and-error approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

PMID: 28564689 [PubMed - indexed for MEDLINE]

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