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Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Author(s): Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Nat Commun. 2020 Jul 28;11(1):3764 Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Article GUID: 32724058
Context controls the timing of responses to an alcohol-predictive conditioned stimulus.

Author(s): Valyear MD, Chaudhri N

Behav Processes. 2020 Feb 01;:104061 Authors: Valyear MD, Chaudhri N

Article GUID: 32017964
Alcohol-seeking and relapse: A focus on incentive salience and contextual conditioning.

Author(s): Valyear MD, Villaruel FR, Chaudhri N

Behav Processes. 2017 Aug;141(Pt 1):26-32 Authors: Valyear MD, Villaruel FR, Chaudhri N

Article GUID: 28473252
Title:Context controls the timing of responses to an alcohol-predictive conditioned stimulus.
Authors:Valyear MD,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/32017964?dopt=Abstract
DOI:10.1016/j.beproc.2020.104061
Category:Behav Processes
PMID:32017964
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Room SP 244, Montreal, QC, H4B-1R6, Canada.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Room SP 244, Montreal, QC, H4B-1R6, Canada. Electronic address: nadia.chaudhri@concordia.ca.

Description:

Context controls the timing of responses to an alcohol-predictive conditioned stimulus.

Behav Processes. 2020 Feb 01;:104061

Authors: Valyear MD, Chaudhri N

Abstract

Context can influence the number of responses elicited by a discrete, appetitive conditioned stimulus (CS) but can context control when a CS elicits a response? To test this fundamental question, we gave male, Long-Evans rats Pavlovian conditioning sessions in which the same auditory conditioned stimulus (CS, 30?s, 15 trials/session) was presented in 2 different physical contexts on alternating days, according to a within-subjects design. In one context, called the early context, alcohol (15% ethanol, 0.2?ml/trial) was delivered from the onset of the 5th second until the termination of the 10th second of the 30?s CS. In the second late context, alcohol was delivered from the onset of the 25th second until the termination of the 30th second of the same CS. In a comparison of the last session of training, the probability of making a conditioned response during the first four seconds of the CS was significantly higher in the early context than in the late context. This result shows that context can signal when an unconditioned stimulus occurs in relation to a CS and highlights a role for context in controlling precisely timed alcohol-seeking responses.

PMID: 32017964 [PubMed - as supplied by publisher]