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Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Author(s): Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Nat Commun. 2020 Jul 28;11(1):3764 Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Article GUID: 32724058
Context controls the timing of responses to an alcohol-predictive conditioned stimulus.

Author(s): Valyear MD, Chaudhri N

Behav Processes. 2020 Feb 01;:104061 Authors: Valyear MD, Chaudhri N

Article GUID: 32017964
Alcohol-seeking and relapse: A focus on incentive salience and contextual conditioning.

Author(s): Valyear MD, Villaruel FR, Chaudhri N

Behav Processes. 2017 Aug;141(Pt 1):26-32 Authors: Valyear MD, Villaruel FR, Chaudhri N

Article GUID: 28473252
Title:Alcohol-seeking and relapse: A focus on incentive salience and contextual conditioning.
Authors:Valyear MD,  Villaruel FR,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/28473252?dopt=Abstract
Category:Behav Processes
PMID:28473252
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology/FRQS Groupe de recherche en neurobiologie comportementale, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Center for Studies in Behavioral Neurobiology/FRQS Groupe de recherche en neurobiologie comportementale, Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: nadia.chaudhri@concordia.ca.

Description:

Alcohol-seeking and relapse: A focus on incentive salience and contextual conditioning.

Behav Processes. 2017 Aug;141(Pt 1):26-32

Authors: Valyear MD, Villaruel FR, Chaudhri N

Abstract

Environmental stimuli that reliably accompany alcohol intake can become associated with the pharmacological effects of alcohol through classical (Pavlovian) conditioning. Of growing interest to addiction researchers is whether or not this process results in the attribution of incentive salience to alcohol-predictive cues, which could motivate alcohol-seeking behavior and relapse. To evaluate this question, we present a review of rodent behavioral studies that examined the capacity of alcohol-predictive cues to (i) support sign-tracking behavior, (ii) serve as conditioned reinforcers, and (iii) produce Pavlovian-to-instrumental transfer. A second, emerging area of research is focused on delineating the role of context in alcohol-seeking behavior and relapse. Here, we review studies showing that alcohol-associated contexts (i) support conditioned place preference, (ii) renew extinguished alcohol-seeking behavior, and (iii) modulate alcohol-seeking responses elicited by discrete alcohol-predictive cues. These behavioral effects may be mediated by unique psychological processes, and have important implications for cue-reactivity studies and neurobiological research.

PMID: 28473252 [PubMed - indexed for MEDLINE]