Keyword search (3,448 papers available)


Prefrontal Cortex and Multiparity in Lactation.

Author(s): Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD

Neuroscience. 2019 Aug 19;: Authors: Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD

Article GUID: 31437474
Gating of the neuroendocrine stress responses by stressor salience in early lactating female rats is independent of infralimbic cortex activation and plasticity.

Author(s): Hillerer KM, Woodside B, Parkinson E, Long H, Verlezza S, Walker CD

Stress. 2018 05;21(3):217-228 Authors: Hillerer KM, Woodside B, Parkinson E, Long H, Verlezza S, Walker CD

Article GUID: 29397787
Automatic and effortful emotional information processing regulates different aspects of the stress response.

Author(s): Ellenbogen MA, Schwartzman AE, Stewart J, Walker CD

Psychoneuroendocrinology. 2006 Apr;31(3):373-87 Authors: Ellenbogen MA, Schwartzman AE, Stewart J, Walker CD

Article GUID: 16289608
Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder.

Author(s): Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S

Psychoneuroendocrinology. 2006 Nov;31(10):1164-80 Authors: Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S

Article GUID: 17055665
High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.

Author(s): Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Bipolar Disord. 2010 Feb;12(1):77-86 Authors: Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Article GUID: 20148869
Sensitivity to stress among the offspring of parents with bipolar disorder: a study of daytime cortisol levels.

Author(s): Ostiguy CS, Ellenbogen MA, Walker CD, Walker EF, Hodgins S

Psychol Med. 2011 Nov;41(11):2447-57 Authors: Ostiguy CS, Ellenbogen MA, Walker CD, Walker EF, Hodgins S

Article GUID: 21524333
Title:Sensitivity to stress among the offspring of parents with bipolar disorder: a study of daytime cortisol levels.
Authors:Ostiguy CS,  Ellenbogen MA,  Walker CD,  Walker EF,  Hodgins S
Link:https://www.ncbi.nlm.nih.gov/pubmed/21524333?dopt=Abstract
Category:Psychol Med
PMID:21524333
Dept Affiliation: CRDH
1 Centre for Research in Human Development, Concordia University, Montréal, Canada.

Description:

Sensitivity to stress among the offspring of parents with bipolar disorder: a study of daytime cortisol levels.

Psychol Med. 2011 Nov;41(11):2447-57

Authors: Ostiguy CS, Ellenbogen MA, Walker CD, Walker EF, Hodgins S

Abstract

BACKGROUND: It is well known that the hypothalamic-pituitary-adrenal (HPA) axis is compromised in major depression and bipolar disorder. There is increasing evidence that subtle HPA abnormalities, such as elevated cortisol levels, precede the development of an affective disorder. Interpersonal stress is also associated with the development of affective disorders. The present study sought to determine whether interpersonal chronic and episodic stress moderated the relationship between cortisol levels in the natural environment and risk status, defined as having a parent with bipolar disorder.

METHOD: Sixty-two offspring of parents with bipolar disorder (OBD) and 60 offspring with no family history of affective disorders (OFH-), aged 19.48 years (s.d.=3.38, range 14-28), completed interviews assessing mental disorders and chronic and episodic stress, and provided saliva samples over 3 days.

RESULTS: Regression analyses revealed that the OBD who experienced high interpersonal chronic stress displayed a larger cortisol rise following awakening than the OBD reporting low interpersonal chronic stress. The same relationship was also found for levels of non-interpersonal chronic stress. The OBD who reported experiencing severe interpersonal episodic stress exhibited higher levels of daytime cortisol than the OBD reporting interpersonal episodic stress of mild severity. Importantly, none of the above relationships were detected in the OFH-. Each of the interactions between family history of affective disorders and stress remained after controlling for age, gender and offspring lifetime affective disorders and current non-affective disorders.

CONCLUSIONS: A biological sensitivity to stress may underlie the susceptibility to affective disorders among the OBD.

PMID: 21524333 [PubMed - indexed for MEDLINE]