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Prefrontal Cortex and Multiparity in Lactation.

Author(s): Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD

Neuroscience. 2019 Aug 19;: Authors: Opala EA, Verlezza S, Long H, Rusu D, Woodside B, Walker CD

Article GUID: 31437474
Gating of the neuroendocrine stress responses by stressor salience in early lactating female rats is independent of infralimbic cortex activation and plasticity.

Author(s): Hillerer KM, Woodside B, Parkinson E, Long H, Verlezza S, Walker CD

Stress. 2018 05;21(3):217-228 Authors: Hillerer KM, Woodside B, Parkinson E, Long H, Verlezza S, Walker CD

Article GUID: 29397787
Automatic and effortful emotional information processing regulates different aspects of the stress response.

Author(s): Ellenbogen MA, Schwartzman AE, Stewart J, Walker CD

Psychoneuroendocrinology. 2006 Apr;31(3):373-87 Authors: Ellenbogen MA, Schwartzman AE, Stewart J, Walker CD

Article GUID: 16289608
Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder.

Author(s): Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S

Psychoneuroendocrinology. 2006 Nov;31(10):1164-80 Authors: Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S

Article GUID: 17055665
High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.

Author(s): Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Bipolar Disord. 2010 Feb;12(1):77-86 Authors: Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Article GUID: 20148869
Sensitivity to stress among the offspring of parents with bipolar disorder: a study of daytime cortisol levels.

Author(s): Ostiguy CS, Ellenbogen MA, Walker CD, Walker EF, Hodgins S

Psychol Med. 2011 Nov;41(11):2447-57 Authors: Ostiguy CS, Ellenbogen MA, Walker CD, Walker EF, Hodgins S

Article GUID: 21524333
Title:High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.
Authors:Ellenbogen MA,  Santo JB,  Linnen AM,  Walker CD,  Hodgins S
Link:https://www.ncbi.nlm.nih.gov/pubmed/20148869?dopt=Abstract
Category:Bipolar Disord
PMID:20148869
Dept Affiliation: CRDH
1 Centre for Research in Human Development, Concordia University, Montréal, Quebec, Canada. mark.ellenbogen@concordia.ca

Description:

High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.

Bipolar Disord. 2010 Feb;12(1):77-86

Authors: Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Abstract

OBJECTIVES: The hypothalamic-pituitary-adrenal (HPA) axis is compromised in major depression, bipolar disorder (BD), and in the offspring of parents with major depression. Less is known about the offspring of parents with BD (FH+). The present project provides follow-up to a previous study showing that the adolescent (mean age 16.7 years) FH+ offspring had higher salivary cortisol levels than the offspring of parents with no mental disorder (FH-) throughout the day in their natural environment, and that girls had higher cortisol levels than boys (Ellenbogen MA, Hodgins S, Walker C-D, Adam S, Couture S. Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder. Psychoneuroendocrinology 2006; 31: 1164-1180). The goal of the present study was to determine whether FH+ offspring, approximately two years later, continued to exhibit elevated cortisol levels relative to FH- offspring during two weeks of daily sampling.

METHODS: The present study examined salivary cortisol levels in 24 (18.3 +/- 2.6 years) FH+ and 22 (18.0 +/- 2.3 years) FH- offspring who are part of the same longitudinal cohort as the previous study. Saliva was collected at 1300 h and 1500 h in the natural environment of the offspring during 14 consecutive days.

RESULTS: Multilevel modelling analyses indicated that FH+ offspring had higher afternoon levels of cortisol in their natural environment than FH- offspring, but group differences in slope and gender differences were not found.

CONCLUSIONS: The FH+ offspring exhibited increased daytime secretion of cortisol that, at the level of the group, persisted into late adolescence and young adulthood. Perhaps this change in HPA functioning is associated with an increased vulnerability for the development of an affective disorder.

PMID: 20148869 [PubMed - indexed for MEDLINE]