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Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

Author(s): Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Nutr Res. 2016 May;36(5):408-17 Authors: Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Article GUID: 27101759
Regional adiposity and markers of inflammation in pre-school age children.

Author(s): Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Sci Rep. 2018 Oct 12;8(1):15204 Authors: Delaney KZ, Vanstone CA, Weiler HA, Santosa S

Article GUID: 30315178
Title:Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.
Authors:Yang SQ,  DeGuire JR,  Lavery P,  Mak IL,  Weiler HA,  Santosa S
Link:https://www.ncbi.nlm.nih.gov/pubmed/27101759?dopt=Abstract
DOI:10.1016/j.nutres.2015.12.013
Category:Nutr Res
PMID:27101759
Dept Affiliation: PERFORM
1 School of Dietetics and Human Nutrition, McGill University, Montreal, QC H9X 3V9, Canada.
2 Department of Exercise Science, Concordia University, Montreal, QC H4B 1R6, Canada; Nutrition, Obesity and Metabolism Lab, PERFORM Centre, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: s.santosa@concordia.ca.

Description:

Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

Nutr Res. 2016 May;36(5):408-17

Authors: Yang SQ, DeGuire JR, Lavery P, Mak IL, Weiler HA, Santosa S

Abstract

We hypothesize that conjugated linoleic acid (CLA) may be effective in preventing the changes in total and regional body composition and increases in interleukin (IL) 6 that occur as a result of hypogonadism. Male guinea pigs (n = 40, 70- to 72-week retired breeders) were block randomized by weight into 4 groups: (1) sham surgery (SHAM)/control (CTRL) diet, (2) SHAM/conjugated linoleic acid (CLA) diet (1%), (3) orchidectomy (ORX)/CTRL diet, and (4) ORX/CLA diet. Dual-energy x-ray absorptiometry scans were performed at baseline and week 16 to assess body composition. Serum IL-6 was analyzed using an enzyme-linked immune sorbent assay. Fatty acids (FAs) from visceral and subcutaneous adipose tissue were analyzed using gas chromatography. In ORX/CTRL guinea pigs, percent total body fat increased by 6.1%, and percent lean mass decreased by 6.7% over the 16-week treatment period, whereas no changes were observed for either parameter in ORX/CLA guinea pigs. Guinea pigs fed the CLA diet gained less percent total, upper, and lower body fat than those fed the CTRL diet regardless of surgical treatment. Regional adipose tissue FA composition was reflective of dietary FAs. Serum IL-6 concentrations were not different among groups. In this study, we observed that, in male guinea pigs, hypogonadism resulted in increased fat mass and decreased lean mass. In addition, CLA was effective in reducing gains in body fat and maintaining lean mass in both hypogonadal and intact guinea pigs.

PMID: 27101759 [PubMed - indexed for MEDLINE]