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Environmental Multimedia Modeling System (EMMS) for Health Risk Assessment: Key Influencing Factors and Uncertainties Researches.

Author(s): Yuan J, Chen Z, Ding S, Zhang Q, Jia Y

In this paper, a former developed Environmental Multimedia Modeling System (EMMS) combining with risk assessment Monte Carlo Method (MCM) was further used for exploring the interaction between groundwater and surface water. When using this EMMS-MCM simulati...

Article GUID: 33410257
Transcriptomic analysis suggests the inhibition of DNA damage repair in green alga Raphidocelis subcapitata exposed to roxithromycin.

Author(s): Guo J, Bai Y, Chen Z, Mo J, Li Q, Sun H, Zhang Q

Ecotoxicol Environ Saf. 2020 Jun 03;201:110737 Authors: Guo J, Bai Y, Chen Z, Mo J, Li Q, Sun H, Zhang Q

Article GUID: 32505758
Antagonistic interactions between two MAP kinase cascades in plant development and immune signaling.

Author(s): Sun T, Nitta Y, Zhang Q, Wu D, Tian H, Lee JS, Zhang Y

EMBO Rep. 2018 07;19(7): Authors: Sun T, Nitta Y, Zhang Q, Wu D, Tian H, Lee JS, Zhang Y

Article GUID: 29789386
Title:Transcriptomic analysis suggests the inhibition of DNA damage repair in green alga Raphidocelis subcapitata exposed to roxithromycin.
Authors:Guo J,  Bai Y,  Chen Z,  Mo J,  Li Q,  Sun H,  Zhang Q
Link:https://www.ncbi.nlm.nih.gov/pubmed/32505758?dopt=Abstract
DOI:10.1016/j.ecoenv.2020.110737
Category:Ecotoxicol Environ Saf
PMID:32505758
Dept Affiliation: CHEMISTRY
1 Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity, College of Urban and Environmental Sciences, Northwest University, Xi'an, 710127, China.
2 Department of Building, Civil and Environmental Engineering, Concordia University, Montreal, H3G 1M8, Canada.
3 Department of Chemistry, City University of Hong Kong, Kowloon, Hong Kong.
4 Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity, College of Urban and Environmental Sciences, Northwest University, Xi'an, 710127, China. Electronic address: zhang-qiang@nwu.edu.cn.

Description:

Transcriptomic analysis suggests the inhibition of DNA damage repair in green alga Raphidocelis subcapitata exposed to roxithromycin.

Ecotoxicol Environ Saf. 2020 Jun 03;201:110737

Authors: Guo J, Bai Y, Chen Z, Mo J, Li Q, Sun H, Zhang Q

Abstract

Macrolide antibiotics are common contaminants in the aquatic environment. They are toxic to a wide range of primary producers, inhibiting the algal growth and further hindering the delivery of several ecosystem services. Yet the molecular mechanisms of macrolides in algae remain undetermined. The objectives of this study were therefore to: 1. evaluate whether macrolides at the environmentally relevant level inhibit the growth of algae; and 2. test the hypothesis that macrolides bind to ribosome and inhibit protein translocation in algae, as it does in bacteria. In this study, transcriptomic analysis was applied to elucidate the toxicological mechanism in a model green alga Raphidocelis subcapitata treated with 5 and 90 µg L-1 of a typical macrolide roxithromycin (ROX). While exposure to ROX at 5 µg L-1 for 7 days did not affect algal growth and the transciptome, ROX at 90 µg L-1 resulted in 45% growth inhibition and 2306 (983 up- and 1323 down-regulated) DEGs, which were primarily enriched in the metabolism of energy, lipid, vitamins, and DNA replication and repair pathways. Nevertheless, genes involved in pathways in relation to translation and protein translocation and processing were dysregulated. Surprisingly, we found that genes involved in the base excision repair process were mostly repressed, suggesting that ROX may be genotoxic and cause DNA damage in R. subcapitata. Taken together, ROX was unlikely to pose a threat to green algae in the environment and the mode of action of macrolides in bacteria may not be directly extrapolated to green algae.

PMID: 32505758 [PubMed - as supplied by publisher]