Keyword search (3,448 papers available)


Real-Time Optogenetics System for Controlling Gene Expression Using a Model-Based Design.

Author(s): Soffer G, Perry JM, Shih SCC

Optimization of engineered biological systems requires precise control over the rates and timing of gene expression. Optogenetics is used to dynamically control gene expression as an alternative to conventional chemical-based methods since it provides a mor...

Article GUID: 33543619
Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus.

Author(s): Boisvert MR, Koski KG, Skinner CD

Anal Chem. 2010 Feb 01;82(3):1133-7 Authors: Boisvert MR, Koski KG, Skinner CD

Article GUID: 20063865
Development of a particle-trap preconcentration-soft ionization mass spectrometric technique for the quantification of mercury halides in air

Author(s): Deeds DA; Ghoshdastidar A; Raofie F; Guérette ÉA; Tessier A; Ariya PA;

Measurement of oxidized mercury, Hg(II), in the atmosphere poses a significant analytical challenge as Hg(II) is present at ultra-trace concentrations (picograms per cubic meter air). Current technologies are sufficiently sensitive to measure the total Hg p...

Article GUID: 25837315
Integration of World-to-Chip Interfaces with Digital Microfluidics for Bacterial Transformation and Enzymatic Assays.

Author(s): Moazami E, Perry JM, Soffer G, Husser MC, Shih SCC

Anal Chem. 2019 Apr 16;91(8):5159-5168 Authors: Moazami E, Perry JM, Soffer G, Husser MC, Shih SCC

Article GUID: 30945840
Analyzing the Biochemical Alteration of Green Algae During Chronic Exposure to Triclosan Based on Synchrotron-Based Fourier Transform Infrared Spectromicroscopy.

Author(s): Xin X, Huang G, An C, Weger H, Cheng G, Shen J, Rosendahl S

Anal Chem. 2019 May 31;: Authors: Xin X, Huang G, An C, Weger H, Cheng G, Shen J, Rosendahl S

Article GUID: 31117408
Title:Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus.
Authors:Boisvert MR,  Koski KG,  Skinner CD
Link:https://www.ncbi.nlm.nih.gov/pubmed/20063865?dopt=Abstract
DOI:10.1021/ac902322w
Category:Anal Chem
PMID:20063865
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, Montreal, Quebec, Canada H4B 1R6.

Description:

Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus.

Anal Chem. 2010 Feb 01;82(3):1133-7

Authors: Boisvert MR, Koski KG, Skinner CD

Abstract

Gestational diabetes mellitus (GDM) is a state of hyperglycaemia and increased oxidative stress with onset during pregnancy. Human serum albumin (HSA) was extracted from 26 GDM and 26 nonGDM amniotic fluid samples collected at 15 weeks gestation and analyzed by mass spectrometry. The majority of all albumin isoforms were oxidized with the cysteinylated HSA as the base peak in the deconvoluted spectrum. The HSA peak areas, from a control sample, had 36% relative standard deviation (RSD) across the six experimental days but using the relative isoform distribution improved the precision to 3-6%. The results show that the relative contribution of permanently oxidized HSA was greater (P = 0.002) and reversibly oxidized HSA was lower (P = 0.006) for GDM compared to nonGDM in the samples measured. This implies that the path toward GDM has been set prior to 15 weeks gestation and results in increased protein oxidation.

PMID: 20063865 [PubMed - indexed for MEDLINE]