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Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children.

Author(s): Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, H...

Can J Cardiol. 2020 May;36(5):596-624 Authors: Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S...

Article GUID: 32389335
Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension.

Author(s): Leung AA, Nerenberg K, Daskalopoulou SS, McBrien K, Zarnke KB, Dasgupta K, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Trembla...

Can J Cardiol. 2016 05;32(5):569-88 Authors: Leung AA, Nerenberg K, Daskalopoulou SS, McBrien K, Zarnke KB, Dasgupta K, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean...

Article GUID: 27118291
Sex Differences in Clinical Outcomes After Premature Acute Coronary Syndrome.

Author(s): Pelletier R, Choi J, Winters N, Eisenberg MJ, Bacon SL, Cox J, Daskalopoulou SS, Lavoie KL, Karp I, Shimony A, So D, Thanassoulis G, Pilote ...

Can J Cardiol. 2016 12;32(12):1447-1453 Authors: Pelletier R, Choi J, Winters N, Eisenberg MJ, Bacon SL, Cox J, Daskalopoulou SS, Lavoie KL, Karp I, Shimony A, So D, Thanassoulis G, Pilote L, GENE...

Article GUID: 27683172
Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults.

Author(s): Leung AA, Daskalopoulou SS, Dasgupta K, McBrien K, Butalia S, Zarnke KB, Nerenberg K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cli...

Can J Cardiol. 2017 05;33(5):557-576 Authors: Leung AA, Daskalopoulou SS, Dasgupta K, McBrien K, Butalia S, Zarnke KB, Nerenberg K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Mil...

Article GUID: 28449828
Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.

Author(s): Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Can J Cardiol. 2016 Apr;32(4):539-46 Authors: Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Article GUID: 26577897
Title:Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.
Authors:Gayda M,  Desjardins A,  Lapierre G,  Dupuy O,  Fraser S,  Bherer L,  Juneau M,  White M,  Gremeaux V,  Labelle V,  Nigam A
Link:https://www.ncbi.nlm.nih.gov/pubmed/26577897?dopt=Abstract
DOI:10.1016/j.cjca.2015.07.011
Category:Can J Cardiol
PMID:26577897
Dept Affiliation: PERFORM
1 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada. Electronic address: mathieu.gayda@icm-mhi.org.
2 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada.
3 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada.
4 Laboratory, MOVE (EA6314), Faculty of Sport Sciences, Université de Poitiers, Poitiers, France.
5 Cardiovascular Prevention and Rehabilitation Centre (ÉPIC), Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada; The School of Social Work, McGill University, Montréal, Québec, Canada.
6 Department of Psychology, Perform Centre, Concordia University, Montréal, Québec, Canada; Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.
7 Research Center, Montreal Heart Institute and University of Montréal, Montréal, Québec, Canada; Department of Medicine, Faculty of Medicine, University of Montréal, Montréal, Québec, Canada.
8 CIC INSERM 1432, Plateforme d'Investigation Technologique, Dijon University Hospital, Dijon, France.
9 Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.

Description:

Cerebral Hemodynamics During Exercise and Recovery in Heart Transplant Recipients.

Can J Cardiol. 2016 Apr;32(4):539-46

Authors: Gayda M, Desjardins A, Lapierre G, Dupuy O, Fraser S, Bherer L, Juneau M, White M, Gremeaux V, Labelle V, Nigam A

Abstract

BACKGROUND: The aims of this work were (1) to compare cerebral oxygenation-perfusion (COP), central hemodynamics, and peak oxygen uptake (V?o2peak) in heart transplant recipients (HTRs) vs age-matched healthy controls (AMHCs) during exercise and recovery and (2) to study the relationships between COP, central hemodynamics, and V?o2peak in HTRs and AMHCs.

METHODS: Twenty-six HTRs (3 women) and 27 AMHCs (5 women) were recruited. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamics (impedance cardiography), and left frontal COP (near-infrared spectroscopy) were measured continuously during and after a maximal ergocycle (Ergoline 800S, Bitz, Germany) test.

RESULTS: Compared with AMHCs, HTRs had lower V?o2peak, maximal cardiac index (CImax), and maximal ventilatory variables (P < 0.05). COP was lower during exercise (oxyhemoglobin [?O2Hb], 50% and 75% of V?O2peak, total hemoglobin [?tHb], 100% of V?O2peak; P < 0.05), and recovery in HTRs (?O2Hb, minutes 2-5; ?tHb, minutes 1-5; P < 0.05) compared with AMHCs. End-tidal pressure of CO2 was lower during exercise compared with that in AMHCs (P < 0.0001). In HTRs, CImax was positively correlated with exercise cerebral hemodynamics (R = 0.54-0.60; P < 0.01).

CONCLUSIONS: In HTRs, COP was reduced during exercise and recovery compared with that in AMHCs, potentially because of a combination of blunted cerebral vasodilation by CO2, cerebrovascular dysfunction, reduced cardiac function, and medication. The impaired V?O2peak observed in HTRs was mainly caused by reduced maximal ventilation and CI. In HTRs, COP is impaired and is correlated with cardiac function, potentially impacting cognitive function. Therefore, we need to study which interventions (eg, exercise training) are most effective for improving or normalizing (or both) COP during and after exercise in HTRs.

PMID: 26577897 [PubMed - indexed for MEDLINE]