Keyword search (3,619 papers available)


Fos expression is increased in oxytocin neurons of female rats with a sexually conditioned mate preference for an individual male rat.

Author(s): Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG

Horm Behav. 2019 Oct 21;:104612 Authors: Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG

Article GUID: 31647923
High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.

Author(s): Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Horm Behav. 2016 06;82:56-63 Authors: Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Article GUID: 27154458
Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.

Author(s): Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Horm Behav. 2017 03;89:113-120 Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Article GUID: 28062232
Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.

Author(s): Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Horm Behav. 2018 01;97:56-66 Authors: Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Article GUID: 29080670
Glutamate release in the ventromedial hypothalamus of the female rat during copulation: modulation by estradiol.

Author(s): Georgescu M, Afonso VM, Graham MD, Pfaus JG

Horm Behav. 2014 Feb;65(2):119-26 Authors: Georgescu M, Afonso VM, Graham MD, Pfaus JG

Article GUID: 24333845
Sensitization of sexual behaviors in ovariectomized Long-Evans rats is induced by a subthreshold dose of estradiol benzoate and attenuated by repeated copulation.

Author(s): Jones SL, Pfaus JG

Horm Behav. 2014 Sep;66(4):655-62 Authors: Jones SL, Pfaus JG

Article GUID: 25251978
The inhibitory effects of corncob bedding on sexual behavior in the ovariectomized Long-Evans rat treated with estradiol benzoate are overcome by male cues.

Author(s): Jones SL, Antonie RA, Pfaus JG

Horm Behav. 2015 Jun;72:39-48 Authors: Jones SL, Antonie RA, Pfaus JG

Article GUID: 25960082
Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.

Author(s): Jones SL, Cordeaux E, Germé K, Pfaus JG

Horm Behav. 2015 Jul;73:104-15 Authors: Jones SL, Cordeaux E, Germé K, Pfaus JG

Article GUID: 26163151
RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.

Author(s): Jones SL, Gardner Gregory J, Pfaus JG

Horm Behav. 2015 Sep;75:1-10 Authors: Jones SL, Gardner Gregory J, Pfaus JG

Article GUID: 26210062
Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young.

Author(s): Jonas W, Woodside B

Horm Behav. 2016 Jan;77:167-81 Authors: Jonas W, Woodside B

Article GUID: 26232032
Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat.

Author(s): Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Horm Behav. 2015 Sep;75:70-7 Authors: Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Article GUID: 26278846
Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat.

Author(s): Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Horm Behav. 2019 Mar;109:1-9 Authors: Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Article GUID: 30690029
Title:Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.
Authors:Almey A,  Arena L,  Oliel J,  Shams WM,  Hafez N,  Mancinelli C,  Henning L,  Tsanev A,  Brake WG
Link:https://www.ncbi.nlm.nih.gov/pubmed/28062232?dopt=Abstract
DOI:10.1016/j.yhbeh.2016.12.010
Category:Horm Behav
PMID:28062232
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: anne.almey@gmail.com.
2 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada.
3 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: waqqas19@gmail.com.
4 Centre for Studies in Behavioral Neurobiology (CSBN), Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address: wayne.brake@concordia.ca.

Description:

Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.

Horm Behav. 2017 03;89:113-120

Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Abstract

There are sex differences associated with schizophrenia, as women exhibit later onset of the disorder, less severe symptomatology, and better response to antipsychotic medications. Estrogens are thought to play a role in these sex differences; estrogens facilitate the effects of antipsychotic medications to reduce the positive symptoms of schizophrenia, but it remains unclear whether estrogens protect against the cognitive symptoms of this disorder. Amphetamine sensitization is used to model some symptoms of schizophrenia in rats, including cognitive deficits like excessive perseveration and slower reversal learning. In this experiment female rats were administered a sensitizing regimen of amphetamine to mimic these cognitive symptoms. They were ovariectomized and administered either low or high estradiol replacement as well as chronic administration of the antipsychotic haloperidol, and were assessed in tests of perseveration and reversal learning. Results of these experiments demonstrated that, in amphetamine-sensitized rats, estradiol alone does not affect perseveration or reversal learning. However, low estradiol facilitates a 0.25mg/day dose of haloperidol to reduce perseveration and improve reversal learning. Combined high estradiol and 0.25mg/day haloperidol has no effect on perseveration or reversal learning, but high estradiol facilitates the effects of 0.13mg/day haloperidol to reduce perseveration and improve reversal learning. Thus, in amphetamine-sensitized female rats, 0.25mg/day haloperidol only improved perseveration and reversal learning when estradiol was low, while 0.13mg/day haloperidol only improved these cognitive processes when estradiol was high. These findings suggest that estradiol facilitates the effects of haloperidol to improve perseveration and reversal learning in a dose-dependent manner.

PMID: 28062232 [PubMed - indexed for MEDLINE]