Keyword search (3,619 papers available)


Fos expression is increased in oxytocin neurons of female rats with a sexually conditioned mate preference for an individual male rat.

Author(s): Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG

Horm Behav. 2019 Oct 21;:104612 Authors: Mac Cionnaith CE, Lemay A, Gomez-Perales EL, Robert G, Cernik R, Brake W, Pfaus JG

Article GUID: 31647923
High estrogen and chronic haloperidol lead to greater amphetamine-induced BOLD activation in awake, amphetamine-sensitized female rats.

Author(s): Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Horm Behav. 2016 06;82:56-63 Authors: Madularu D, Kulkarni P, Yee JR, Kenkel WM, Shams WM, Ferris CF, Brake WG

Article GUID: 27154458
Interactions between estradiol and haloperidol on perseveration and reversal learning in amphetamine-sensitized female rats.

Author(s): Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Horm Behav. 2017 03;89:113-120 Authors: Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, Henning L, Tsanev A, Brake WG

Article GUID: 28062232
Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner.

Author(s): Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Horm Behav. 2018 01;97:56-66 Authors: Hyland L, Rosenbaum S, Edwards A, Palacios D, Graham MD, Pfaus JG, Woodside B, Abizaid A

Article GUID: 29080670
Glutamate release in the ventromedial hypothalamus of the female rat during copulation: modulation by estradiol.

Author(s): Georgescu M, Afonso VM, Graham MD, Pfaus JG

Horm Behav. 2014 Feb;65(2):119-26 Authors: Georgescu M, Afonso VM, Graham MD, Pfaus JG

Article GUID: 24333845
Sensitization of sexual behaviors in ovariectomized Long-Evans rats is induced by a subthreshold dose of estradiol benzoate and attenuated by repeated copulation.

Author(s): Jones SL, Pfaus JG

Horm Behav. 2014 Sep;66(4):655-62 Authors: Jones SL, Pfaus JG

Article GUID: 25251978
The inhibitory effects of corncob bedding on sexual behavior in the ovariectomized Long-Evans rat treated with estradiol benzoate are overcome by male cues.

Author(s): Jones SL, Antonie RA, Pfaus JG

Horm Behav. 2015 Jun;72:39-48 Authors: Jones SL, Antonie RA, Pfaus JG

Article GUID: 25960082
Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.

Author(s): Jones SL, Cordeaux E, Germé K, Pfaus JG

Horm Behav. 2015 Jul;73:104-15 Authors: Jones SL, Cordeaux E, Germé K, Pfaus JG

Article GUID: 26163151
RU486 facilitates or disrupts the sensitization of sexual behaviors by estradiol in the ovariectomized Long-Evans rat: Effect of timecourse.

Author(s): Jones SL, Gardner Gregory J, Pfaus JG

Horm Behav. 2015 Sep;75:1-10 Authors: Jones SL, Gardner Gregory J, Pfaus JG

Article GUID: 26210062
Physiological mechanisms, behavioral and psychological factors influencing the transfer of milk from mothers to their young.

Author(s): Jonas W, Woodside B

Horm Behav. 2016 Jan;77:167-81 Authors: Jonas W, Woodside B

Article GUID: 26232032
Vaginocervical stimulation attenuates the sensitization of appetitive sexual behaviors by estradiol benzoate in the ovariectomized rat.

Author(s): Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Horm Behav. 2015 Sep;75:70-7 Authors: Jones SL, Germé K, Graham MD, Roy P, Gardner Gregory J, Rosenbaum S, Parada M, Pfaus JG

Article GUID: 26278846
Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat.

Author(s): Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Horm Behav. 2019 Mar;109:1-9 Authors: Gerson CA, Mac Cionnaith CE, Quintana GR, Pfaus JG

Article GUID: 30690029
Title:Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.
Authors:Jones SL,  Cordeaux E,  Germé K,  Pfaus JG
Link:https://www.ncbi.nlm.nih.gov/pubmed/26163151?dopt=Abstract
Category:Horm Behav
PMID:26163151
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: sljones@live.concordia.ca.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada.

Description:

Behavioral defeminization by prenatal androgen treatment in rats can be overcome by sexual experience in adulthood.

Horm Behav. 2015 Jul;73:104-15

Authors: Jones SL, Cordeaux E, Germé K, Pfaus JG

Abstract

Exposure to testosterone during a critical period of prenatal development disrupts the normal display of sexual behaviors in adult ovariectomized (OVX) rats treated with estradiol benzoate (EB) followed by progesterone (P). The organizational hypothesis posits that prenatally androgenized females (PNAFs) are desensitized to EB. We tested this hypothesis by first treating PNAFs with varying doses of EB (2.5, 5, 10, 20µg) followed by P (500µg), and second by subjecting females to an established EB behavioral sensitization paradigm where females are first given sexual experience with EB (10µg) and P prior to repeated sexual behavior testing with EB alone. Long-Evans females were androgenized in utero by a s.c. injection of 500µg testosterone propionate or the oil control to pregnant dams on gestational day 18. Female offspring were OVX on postnatal day 80 and tested one week later in the unilevel 4-hole pacing chamber. Genital tissue was defeminized in PNAFs, and the lordosis quotient (LQ) and partial (i.e., hops/darts) and full solicitations were significantly lower, while defensive behaviors were higher, in PNAF females, relative to non-PNAF females regardless of the acute EB priming dose. However, repeated testing with EB alone (10µg), or EB and P eliminated the differences between groups on LQ and hops/darts, indicating that the behavioral deficit can be overcome by sexual experience. These results suggest that PNAFs are not desensitized to EB, and despite disruptions in sexual differentiation of anatomical structures, the deficiency in sexual behavior in response to acute EB and P can be experientially overcome. PNAFs appear, however, to have a chronic deficit in the expression of full solicitations.

PMID: 26163151 [PubMed - indexed for MEDLINE]