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Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.

Author(s): Hayward DA, Pomares F, Casey KF, Ismaylova E, Levesque M, Greenlaw K, Vitaro F, Brendgen M, Rénard F, Dionne G, Boivin M, Tremblay RE, Booij...

Previous research has shown that the prenatal environment, commonly indexed by birth weight (BW), is a predictor of morphological brain development. We previously showed in monozygotic (MZ) twins a...

Article GUID: 32881198
Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.

Author(s): Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Hum Brain Mapp. 2020 May 09;: Authors: Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Article GUID: 32386115
Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.

Author(s): Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Hum Brain Mapp. 2017 04;38(4):2037-2050 Authors: Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Article GUID: 28032437
Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy.

Author(s): Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E

Hum Brain Mapp. 2016 May;37(5):1661-83 Authors: Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E

Article GUID: 26931511
Source localization of the seizure onset zone from ictal EEG/MEG data.

Author(s): Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2016 07;37(7):2528-46 Authors: Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 27059157
Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Author(s): Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Hum Brain Mapp. 2018 01;39(1):218-231 Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 29024165
Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.

Author(s): Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2018 02;39(2):880-901 Authors: Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 29164737
Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.

Author(s): Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP...

Hum Brain Mapp. 2017 04;38(4):2276-2325 Authors: Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van G...

Article GUID: 28145075
Title:Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.
Authors:Casey KF,  Levesque ML,  Szyf M,  Ismaylova E,  Verner MP,  Suderman M,  Vitaro F,  Brendgen M,  Dionne G,  Boivin M,  Tremblay RE,  Booij L
Link:https://www.ncbi.nlm.nih.gov/pubmed/28032437?dopt=Abstract
DOI:10.1002/hbm.23503
Category:Hum Brain Mapp
PMID:28032437
Dept Affiliation: PSYCHOLOGY
1 CHU Sainte-Justine Research Center, Montreal, Québec, Canada.
2 Department of Psychiatry, University of Montreal, Montreal, Québec, Canada.
3 Department of Pharmacology and Therapeutics, McGill University, Montreal, Québec, Canada.
4 Department of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
5 Psychoeducation, University of Montreal, Montreal, Québec, Canada.
6 Department of Psychology, UQAM, Montreal, Québec, Canada.
7 School of Psychology, University of Laval, Québec City, Québec, Canada.
8 Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Tomsk, Siberia, Russian Federation.
9 Department of Psychology & Pediatrics, University of Montreal, Montreal, Québec, Canada.
10 School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland.
11 Department of Psychology, Concordia University, Montreal, Québec, Canada.
12 Department of Psychiatry, McGill University, Montreal, Québec, Canada.

Description:

Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.

Hum Brain Mapp. 2017 04;38(4):2037-2050

Authors: Casey KF, Levesque ML, Szyf M, Ismaylova E, Verner MP, Suderman M, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L

Abstract

BACKGROUND: Several studies have shown that the in utero environment, which can be indexed by birth weight (BW), is associated with cortical morphology in adolescence and adulthood. Work in monozygotic (MZ) twins suggests that this association is driven by non-shared environmental factors. This correlation could be the result of in utero impacts on DNA methylation. The aim of the present study with MZ twins is to replicate the association between discordance in BW and brain morphology and test whether discordance in DNA methylation mediates this relationship.

METHODS: One hundred and four adolescent MZ twins (52 pairs, of which 42% were male pairs) who have been followed regularly since birth underwent T1 weighted structural MRI, and epigenome-wide assessment of DNA methylation from saliva at age 15.

RESULTS: Co-twins had very similar measures of DNA methylation and cortical morphology. Higher BW members of a twin pair had increased total cortical surface area, and decreased cortical thickness compared to their lower BW sibling. BW Discordance was positively associated with both cortical surface area and cortical volume discordance. Genes involved in neurodevelopment were tentatively identified as mediators of both the BW - cortical volume, and BW- cortical surface area relationships.

CONCLUSIONS: The association between BW and cortical morphology in adolescence appears to be attributable to in utero environmental effects, and DNA methylation may play a role in mediating this relationship. Hum Brain Mapp 38:2037-2050, 2017. © 2017 Wiley Periodicals, Inc.

PMID: 28032437 [PubMed - indexed for MEDLINE]