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Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.

Author(s): Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Int J Mol Sci. 2020 Jul 02;21(13): Authors: Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Article GUID: 32630624
Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.

Author(s): Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Int J Mol Sci. 2019 Dec 05;20(24): Authors: Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Article GUID: 31817343
Aging and Age-related Disorders: From Molecular Mechanisms to Therapies.

Author(s): Titorenko VI

Int J Mol Sci. 2019 Jul 03;20(13): Authors: Titorenko VI

Article GUID: 31277345
Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment

Author(s): Malkawi AK; Masood A; Shinwari Z; Jacob M; Benabdelkamel H; Matic G; Almuhanna F; Dasouki M; Alaiya AA; Rahman AMA;...

Prolonged dexamethasone (Dex) administration leads to serious adverse and decrease brain and heart size, muscular atrophy, hemorrhagic liver, and presence of kidney cysts. Herein, we used an untarg...

Article GUID: 31247941
Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2018 Mar 15;19(3): Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29543708
Molecular and Cellular Mechanisms of Aging and Age-related Disorders.

Author(s): Titorenko VI

Int J Mol Sci. 2018 Jul 14;19(7): Authors: Titorenko VI PMID: 30011889 [PubMed - indexed for MEDLINE]

Article GUID: 30011889
The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.

Author(s): Busby M, Hallett MT, Plante I

Int J Mol Sci. 2018 Feb 28;19(3): Authors: Busby M, Hallett MT, Plante I

Article GUID: 29495625
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Author(s): Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2019 May 01;20(9): Authors: Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Article GUID: 31052375
Title:Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment
Authors:Malkawi AK,  Masood A,  Shinwari Z,  Jacob M,  Benabdelkamel H,  Matic G,  Almuhanna F,  Dasouki M,  Alaiya AA,  Rahman AMA, 
Link:https://pubmed.ncbi.nlm.nih.gov/31247941/
DOI:10.3390/ijms20133122
Category:Int J Mol Sci
PMID:31247941
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrook Street West, Montréal, QC H4B 1R6, Canada.
2 Department of Comparative Medicine, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh 11461, Saudi Arabia.
3 Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi Arabia.
4 Stem Cell & Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh 11461, Saudi Arabia.
5 Department of Genetics, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh 11461, Saudi Arabia.
6 College of Public Health, Medical, and Veterinary Sciences/Molecular & Cell Biology, James Cook University, Townsville, QLD 4811, Australia.
7 Department of Genetics, King Faisal Specialist Hospital and Research Center (KFSHRC), Riyadh 11461, Saudi Arabia. aabdelrahman46@kfshrc.edu.sa.
8 College of Medicine, Al Faisal University, Riyadh 11533, Saudi Arabia. aabdelrahman46@kfshrc.edu.sa.
9 Department of Chemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X7, Canada. aabdelrahman46@kfshrc.edu.sa.

Description:

Prolonged dexamethasone (Dex) administration leads to serious adverse and decrease brain and heart size, muscular atrophy, hemorrhagic liver, and presence of kidney cysts. Herein, we used an untargeted proteomic approach using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneous identification of changes in proteomes of the major organs in Sprague-Dawley (SD rats post Dex treatment. The comparative and quantitative proteomic analysis of the brain, heart, muscle, liver, and kidney tissues revealed differential expression of proteins (n = 190, 193, 39, 230, and 53, respectively) between Dex-treated and control rats. Functional network analysis using ingenuity pathway analysis (IPA revealed significant differences in regulation of metabolic pathways within the morphologically changed organs that related to: (i) brain-cell morphology, nervous system development, and function and neurological disease; (ii) heart-cellular development, cellular function and maintenance, connective tissue development and function; (iii) skeletal muscle-nucleic acid metabolism, and small molecule biochemical pathways; (iv) liver-lipid metabolism, small molecular biochemistry, and nucleic acid metabolism; and (v) kidney-drug metabolism, organism injury and abnormalities, and renal damage. Our study provides a comprehensive description of the organ-specific proteomic profilesand differentially altered biochemical pathways, after prolonged Dex treatement to understand the molecular basis for development of side effects.