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Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.

Author(s): Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Int J Mol Sci. 2020 Jul 02;21(13): Authors: Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Article GUID: 32630624
Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.

Author(s): Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Int J Mol Sci. 2019 Dec 05;20(24): Authors: Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Article GUID: 31817343
Aging and Age-related Disorders: From Molecular Mechanisms to Therapies.

Author(s): Titorenko VI

Int J Mol Sci. 2019 Jul 03;20(13): Authors: Titorenko VI

Article GUID: 31277345
Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment

Author(s): Malkawi AK; Masood A; Shinwari Z; Jacob M; Benabdelkamel H; Matic G; Almuhanna F; Dasouki M; Alaiya AA; Rahman AMA;...

Prolonged dexamethasone (Dex) administration leads to serious adverse and decrease brain and heart size, muscular atrophy, hemorrhagic liver, and presence of kidney cysts. Herein, we used an untarg...

Article GUID: 31247941
Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2018 Mar 15;19(3): Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29543708
Molecular and Cellular Mechanisms of Aging and Age-related Disorders.

Author(s): Titorenko VI

Int J Mol Sci. 2018 Jul 14;19(7): Authors: Titorenko VI PMID: 30011889 [PubMed - indexed for MEDLINE]

Article GUID: 30011889
The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.

Author(s): Busby M, Hallett MT, Plante I

Int J Mol Sci. 2018 Feb 28;19(3): Authors: Busby M, Hallett MT, Plante I

Article GUID: 29495625
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Author(s): Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2019 May 01;20(9): Authors: Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Article GUID: 31052375
Title:The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.
Authors:Busby M,  Hallett MT,  Plante I
Link:https://www.ncbi.nlm.nih.gov/pubmed/29495625?dopt=Abstract
DOI:10.3390/ijms19030693
Category:Int J Mol Sci
PMID:29495625
Dept Affiliation: BIOLOGY
1 INRS-Institut Armand-Frappier, Laval, QC H7V 1B7, Canada. melanie.busby@inrs.iaf.ca.
2 Centre for Structural and Functional Genomics, Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada. michael.hallett@concordia.ca.
3 INRS-Institut Armand-Frappier, Laval, QC H7V 1B7, Canada. Isabelle.Plante@iaf.inrs.ca.

Description:

The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.

Int J Mol Sci. 2018 Feb 28;19(3):

Authors: Busby M, Hallett MT, Plante I

Abstract

Gap junction transmembrane channels allow the transfer of small molecules between the cytoplasm of adjacent cells. They are formed by proteins named connexins (Cxs) that have long been considered as a tumor suppressor. This widespread view has been challenged by recent studies suggesting that the role of Connexin 43 (Cx43) in cancer is tissue- and stage-specific and can even promote tumor progression. High throughput profiling of invasive breast cancer has allowed for the construction of subtyping schemes that partition patients into at least four distinct intrinsic subtypes. This study characterizes Cx43 expression during cancer progression with each of the tumor subtypes using a compendium of publicly available gene expression data. In particular, we show that Cx43 expression depends greatly on intrinsic subtype. Tumor grade also co-varies with patient subtype, resulting in Cx43 co-expression with grade in a subtype-dependent manner. Better survival was associated with a high expression of Cx43 in unstratified and luminal tumors but with a low expression in Her2e subtype. A better understanding of Cx43 regulation in a subtype-dependent manner is needed to clarify the context in which Cx43 is associated with tumor suppression or cancer progression.

PMID: 29495625 [PubMed - indexed for MEDLINE]