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Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.

Author(s): Charlton DE, Nikjoo H, Humm JL

Int J Radiat Biol. 1989 Jul;56(1):1-19 Authors: Charlton DE, Nikjoo H, Humm JL

Article GUID: 2569005
Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.

Author(s): Charlton DE, Allen BJ

Int J Radiat Biol. 1993 Dec;64(6):739-47 Authors: Charlton DE, Allen BJ

Article GUID: 7903342
Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.

Author(s): Charlton DE, Turner MS

Int J Radiat Biol. 1996 Feb;69(2):213-7 Authors: Charlton DE, Turner MS PMID: 8609458 [PubMed - indexed for MEDLINE]

Article GUID: 8609458
Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.

Author(s): Charlton DE, Utteridge TD, Beddoe AH

Int J Radiat Biol. 1996 May;69(5):585-92 Authors: Charlton DE, Utteridge TD, Beddoe AH

Article GUID: 8648246
Radiation effects in spheroids of cells exposed to alpha emitters.

Author(s): Charlton DE

Int J Radiat Biol. 2000 Nov;76(11):1555-64 Authors: Charlton DE

Article GUID: 11098858
Title:Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.
Authors:Charlton DE,  Utteridge TD,  Beddoe AH
Link:https://www.ncbi.nlm.nih.gov/pubmed/8648246?dopt=Abstract
Category:Int J Radiat Biol
PMID:8648246
Dept Affiliation: PHYSICS

Description:

Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.

Int J Radiat Biol. 1996 May;69(5):585-92

Authors: Charlton DE, Utteridge TD, Beddoe AH

Abstract

The Monte Carlo method is used to model fat cells and the nuclei of stem cells in haemopoietic tissue where 222Rn is dissolved in different amounts in the fat and tissue. Calculations are performed for fat cells of diameters 50 and 100 microns and for stem cell nuclei of 8 and 16 microns diameters for various fractions of fat filling the volume. Average doses (and their distributions) to stem cell nuclei from single passages of alpha particles are presented. In addition to dose, the relationship between LET and dose is obtained, illustrating the importance of 'stoppers' in the calculations. The annual average dose equivalent for a concentration of 1 Bq/m3 in air agrees well with other authors at 12 mu Sv/year. The method also allows the calculation of the fraction of stem cell nuclei hit annually. Here for 1 Bq/m3, stem cell nuclei of diameter 8 microns and 100% fat filing 15 x 10(-7) of the stem cell nuclei are hit.

PMID: 8648246 [PubMed - indexed for MEDLINE]