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Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.

Author(s): Charlton DE, Nikjoo H, Humm JL

Int J Radiat Biol. 1989 Jul;56(1):1-19 Authors: Charlton DE, Nikjoo H, Humm JL

Article GUID: 2569005
Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.

Author(s): Charlton DE, Allen BJ

Int J Radiat Biol. 1993 Dec;64(6):739-47 Authors: Charlton DE, Allen BJ

Article GUID: 7903342
Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.

Author(s): Charlton DE, Turner MS

Int J Radiat Biol. 1996 Feb;69(2):213-7 Authors: Charlton DE, Turner MS PMID: 8609458 [PubMed - indexed for MEDLINE]

Article GUID: 8609458
Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.

Author(s): Charlton DE, Utteridge TD, Beddoe AH

Int J Radiat Biol. 1996 May;69(5):585-92 Authors: Charlton DE, Utteridge TD, Beddoe AH

Article GUID: 8648246
Radiation effects in spheroids of cells exposed to alpha emitters.

Author(s): Charlton DE

Int J Radiat Biol. 2000 Nov;76(11):1555-64 Authors: Charlton DE

Article GUID: 11098858
Title:Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.
Authors:Charlton DE,  Allen BJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/7903342?dopt=Abstract
Category:Int J Radiat Biol
PMID:7903342
Dept Affiliation: PHYSICS

Description:

Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.

Int J Radiat Biol. 1993 Dec;64(6):739-47

Authors: Charlton DE, Allen BJ

Abstract

The Monte Carlo technique is used to examine the passage of ions from the (n, p) reaction in nitrogen and the (n, alpha) reaction in 10B through the nuclei of endothelial capillary wall cells of normal white matter. Contributions to the dose from different regions are evaluated, as is the distribution of doses to the nuclei for mean doses from 1 to 100 Gy. Calculation of mean dose to the nuclei is generalized for any neutron fluence and element concentration. The dose-averaged LETs for both reactions are found giving (for the particular conditions of the calculation); 60 keV/microns for the (n, p) reaction and 216 keV/micron for the (n, alpha) reaction in boron limited to the lumen, and 224 keV/micron for a uniform distribution of boron. From a consideration of 'minimal survival' and hit and dose distributions, evidence is presented which suggests that the RBE for the (n, alpha) reaction depends upon the distribution of the boron in the tissue, with the uniform distribution being less effective at cell killing than the boron restricted to the lumen for the same mean dose to the cell nuclei.

PMID: 7903342 [PubMed - indexed for MEDLINE]