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DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

Author(s): Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

J Affect Disord. 2020 Jun 15;271:160-168 Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Article GUID: 32479312
Interpersonal functioning in adolescent offspring of parents with bipolar disorder.

Author(s): Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

J Affect Disord. 2009 Apr;114(1-3):122-30 Authors: Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

Article GUID: 18692905
Chronic stress and stressful life events in the offspring of parents with bipolar disorder.

Author(s): Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

J Affect Disord. 2009 Apr;114(1-3):74-84 Authors: Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

Article GUID: 18814916
Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?

Author(s): Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

J Affect Disord. 2011 Jul;132(1-2):265-9 Authors: Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

Article GUID: 21329985
Personality, coping, risky behavior, and mental disorders in the offspring of parents with bipolar disorder: a comprehensive psychosocial assessment.

Author(s): Nijjar R, Ellenbogen MA, Hodgins S

J Affect Disord. 2014 Sep;166:315-23 Authors: Nijjar R, Ellenbogen MA, Hodgins S

Article GUID: 25012447
Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults.

Author(s): McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

J Affect Disord. 2019 Apr 22;253:366-375 Authors: McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

Article GUID: 31078837
Title:Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults.
Authors:McIver TA,  Bosma RL,  Goegan S,  Sandre A,  Klassen J,  Chiarella J,  Booij L,  Craig W
Link:https://www.ncbi.nlm.nih.gov/pubmed/31078837?dopt=Abstract
Category:J Affect Disord
PMID:31078837
Dept Affiliation: PSYCHOLOGY
1 Centre for Neuroscience Studies, Queen's University, Botterell Hall, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada.
2 Department of Psychology, Queen's University, Humphrey Hall, 62 Arch Street, Kingston, Ontario, K7L 3N6, Canada.
3 Department of Psychology, Queen's University, Humphrey Hall, 62 Arch Street, Kingston, Ontario, K7L 3N6, Canada; Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, Québec H4B 1R6, Canada. Electronic address: linda.booij@concordia.ca.

Description:

Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults.

J Affect Disord. 2019 Apr 22;253:366-375

Authors: McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

Abstract

BACKGROUND: Peer victimization is associated with increased risk for depression, as well as increased neural response to social exclusion in the anterior cingulate cortex (ACC) and the amygdala. Altered functional connectivity (FxC) of fronto-limbic circuitry is associated with risk for various affective disorders. The present study examined the relationship between fronto-limbic FxC during social exclusion, prior peer victimization experience and depressive symptoms.

METHODS: Three mutually exclusive groups were formed: peer victimized (with a history of peer victimization), defenders (history of defending peers), and controls (no prior peer victimization experience) (n?=?15/group; Mage?=?17.7 years). Functional Magnetic Resonance Imaging data were collected while participants completed the Cyberball paradigm (simulating the experience of social exclusion). FxC between the Medial Prefrontal Cortex (MPFC), ACC, right insula and left amygdala, was compared between groups and examined in relation to depressive symptoms.

RESULTS: Prior peer victimization experience was associated with differences in fronto-limbic FxC across social inclusion and exclusion. Defenders displayed distinct shifts in FxC across the transition from being included to excluded. Peer victimized individuals exhibited a unique pattern of amygdala-specific FxC during inclusive interaction with peers, and in the continuous FxC across inclusion and exclusion. FxC of the MPFC-amygdala across inclusion and exclusion moderated the relationship between peer victimization and depressive symptoms.

LIMITATIONS: Small sample size and cross-sectional design limit interpretation of the findings.

CONCLUSIONS: Peer victimized individuals who exhibit continuous positive FxC of the MPFC-left amygdala across inclusion and exclusion may be at greater risk for depressive symptoms.

PMID: 31078837 [PubMed - as supplied by publisher]