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DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents.

Author(s): Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

J Affect Disord. 2020 Jun 15;271:160-168 Authors: Chiarella J, Schumann L, Pomares FB, Frodl T, Tozzi L, Nemoda Z, Yu P, Szyf M, Khalid-Khan S, Booij L

Article GUID: 32479312
Interpersonal functioning in adolescent offspring of parents with bipolar disorder.

Author(s): Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

J Affect Disord. 2009 Apr;114(1-3):122-30 Authors: Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

Article GUID: 18692905
Chronic stress and stressful life events in the offspring of parents with bipolar disorder.

Author(s): Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

J Affect Disord. 2009 Apr;114(1-3):74-84 Authors: Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

Article GUID: 18814916
Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?

Author(s): Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

J Affect Disord. 2011 Jul;132(1-2):265-9 Authors: Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

Article GUID: 21329985
Personality, coping, risky behavior, and mental disorders in the offspring of parents with bipolar disorder: a comprehensive psychosocial assessment.

Author(s): Nijjar R, Ellenbogen MA, Hodgins S

J Affect Disord. 2014 Sep;166:315-23 Authors: Nijjar R, Ellenbogen MA, Hodgins S

Article GUID: 25012447
Functional connectivity across social inclusion and exclusion is related to peer victimization and depressive symptoms in young adults.

Author(s): McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

J Affect Disord. 2019 Apr 22;253:366-375 Authors: McIver TA, Bosma RL, Goegan S, Sandre A, Klassen J, Chiarella J, Booij L, Craig W

Article GUID: 31078837
Title:Personality, coping, risky behavior, and mental disorders in the offspring of parents with bipolar disorder: a comprehensive psychosocial assessment.
Authors:Nijjar R,  Ellenbogen MA,  Hodgins S
Link:https://www.ncbi.nlm.nih.gov/pubmed/25012447?dopt=Abstract
Category:J Affect Disord
PMID:25012447
Dept Affiliation: CRDH
1 Centre for Research in Human Development, Concordia University, Montreal, Canada.
2 Centre for Research in Human Development, Concordia University, Montreal, Canada. Electronic address: mark.ellenbogen@concordia.ca.
3 Département de Psychiatrie, Université de Montréal, Montréal, Canada; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

Description:

Personality, coping, risky behavior, and mental disorders in the offspring of parents with bipolar disorder: a comprehensive psychosocial assessment.

J Affect Disord. 2014 Sep;166:315-23

Authors: Nijjar R, Ellenbogen MA, Hodgins S

Abstract

OBJECTIVES: It has been proposed that the offspring of parents with bipolar disorder (OBD), through genetic mechanisms and early family interactions, develop a heightened sensitivity to stress, maladaptive coping, and dysregulated behavior, which ultimately increases the risk for affective disorders. The current study tested certain predictions of this model by assessing different psychosocial and health-related outcomes in the OBD, including personality, coping style, smoking, suicidality, high-risk sexual behaviors, criminality, and mental health.

METHOD: The sample was composed of 74 OBD and 75 control offspring, who were between 14 and 27 years of age (mean: 19.38±3.56). Participants underwent a diagnostic interview and a structured interview to assess high-risk behavior and other maladaptive outcomes, and they completed the Revised NEO Personality Inventory and Coping in Stressful Situations questionnaire.

RESULTS: The rates of affective (31.1%) and non-affective (56.8%) disorders were elevated in the OBD compared to controls (9.5% and 32.4%). Relative to controls, OBD endorsed fewer task-oriented and more distraction coping strategies [Wilk?s ?=.83, F(1, 136) =6.92, p<.01], and were more likely to report engaging in high-risk sexual behavior (OR=2.37; Wald=4.13, 1 df, p<05). Importantly, OBD reported elevated high-risk sexual behavior relative to controls, irrespective of affective disorder diagnosis.

CONCLUSION: The results highlight a potential risk profile for the OBD, consisting of ineffective coping strategies and risky sexual behavior and are discussed in the context of current knowledge of stress and coping in this population.

LIMITATIONS: The present findings were based on cross-sectional data and relied on offspring self-report. It would be useful to corroborate these findings with biobehavioural and longitudinal measures.

PMID: 25012447 [PubMed - indexed for MEDLINE]