Keyword search (3,619 papers available)


Auditory information enhances post-sensory visual evidence during rapid multisensory decision-making.

Author(s): Franzen L; Delis I; De Sousa G; Kayser C; Philiastides MG;

Despite recent progress in understanding multisensory decision-making, a conclusive mechanistic account of how the brain translates the relevant evidence into a decision is lacking. Specifically, it remains unclear whether perceptual improvements during rap...

Article GUID: 33116148
Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Author(s): Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Nat Commun. 2020 Jul 28;11(1):3764 Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Article GUID: 32724058
A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids.

Author(s): Pyne ME, Kevvai K, Grewal PS, Narcross L, Choi B, Bourgeois L, Dueber JE, Martin VJJ

Nat Commun. 2020 Jul 03;11(1):3337 Authors: Pyne ME, Kevvai K, Grewal PS, Narcross L, Choi B, Bourgeois L, Dueber JE, Martin VJJ

Article GUID: 32620756
Evolving perspectives on the sources of the frequency-following response.

Author(s): Coffey EBJ, Nicol T, White-Schwoch T, Chandrasekaran B, Krizman J, Skoe E, Zatorre RJ, Kraus N

Nat Commun. 2019 Nov 06;10(1):5036 Authors: Coffey EBJ, Nicol T, White-Schwoch T, Chandrasekaran B, Krizman J, Skoe E, Zatorre RJ, Kraus N

Article GUID: 31695046
Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.

Author(s): Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA

Nat Commun. 2019 Oct 11;10(1):4665 Authors: Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA

Article GUID: 31604953
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.

Author(s): Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Les...

Nat Commun. 2019 Sep 17;10(1):4227 Authors: Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, ...

Article GUID: 31530809
Author Correction: Building a global alliance of biofoundries.

Author(s): Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, John...

Nat Commun. 2019 Jul 11;10(1):3132 Authors: Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR,...

Article GUID: 31296848
Neural correlates of two different types of extinction learning in the amygdala central nucleus.

Author(s): Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Nat Commun. 2016 08 17;7:12330 Authors: Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Article GUID: 27531638
The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation.

Author(s): McNally EK, Brett CL

Nat Commun. 2018 12 18;9(1):5358 Authors: McNally EK, Brett CL

Article GUID: 30560896
A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host.

Author(s): Harding CM, Nasr MA, Scott NE, Goyette-Desjardins G, Nothaft H, Mayer AE, Chavez SM, Huynh JP, Kinsella RL, Szymanski CM, Stallings CL, Segu...

Nat Commun. 2019 02 21;10(1):891 Authors: Harding CM, Nasr MA, Scott NE, Goyette-Desjardins G, Nothaft H, Mayer AE, Chavez SM, Huynh JP, Kinsella RL, Szymanski CM, Stallings CL, Segura M, Feldman MF

Article GUID: 30792408
Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae.

Author(s): Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ

Nat Commun. 2014;5:3283 Authors: Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ

Article GUID: 24513861
Giant electron-hole transport asymmetry in ultra-short quantum transistors.

Author(s): McRae AC, Tayari V, Porter JM, Champagne AR

Nat Commun. 2017 05 31;8:15491 Authors: McRae AC, Tayari V, Porter JM, Champagne AR

Article GUID: 28561024
Building a global alliance of biofoundries.

Author(s): Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Jo...

Nat Commun. 2019 05 09;10(1):2040 Authors: Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR...

Article GUID: 31068573
Title:Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.
Authors:Hadoux X,  Hui F,  Lim JKH,  Masters CL,  Pébay A,  Chevalier S,  Ha J,  Loi S,  Fowler CJ,  Rowe C,  Villemagne VL,  Taylor EN,  Fluke C,  Soucy JP,  Lesage F,  Sylvestre JP,  Rosa-Neto P,  Mathotaarachchi S,  Gauthier S,  Nasreddine ZS,  Arbour JD,  Rhéaume MA,  Beaulieu S,  Dirani M,  Nguyen CTO,  Bui BV,  Williamson R,  Crowston JG,  van Wijngaarden P
Link:https://www.ncbi.nlm.nih.gov/pubmed/31530809?dopt=Abstract
DOI:10.1038/s41467-019-12242-1
Category:Nat Commun
PMID:31530809
Dept Affiliation: PERFORM
1 Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, 3002, VIC, Australia. xavier.hadoux@unimelb.edu.au.
2 Ophthalmology, Department of Surgery, University of Melbourne, Parkville, 3010, VIC, Australia. xavier.hadoux@unimelb.edu.au.
3 Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, 3002, VIC, Australia.
4 Ophthalmology, Department of Surgery, University of Melbourne, Parkville, 3010, VIC, Australia.
5 Department of Optometry and Vision Sciences, University of Melbourne, Parkville, 3010, VIC, Australia.
6 The Florey Institute, The University of Melbourne, Parkville, 3010, VIC, Australia.
7 Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, 3800, VIC, Australia.
8 Neuropsychiatry Unit, North Western Mental Health, Melbourne Health, Royal Melbourne Hospital, Parkville, 3050, VIC, Australia.
9 University of Melbourne, Department of Psychiatry, Parkville, 3010, VIC, Australia.
10 Austin Health, Melbourne, 3084, VIC, Australia.
11 Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Melbourne, 3122, VIC, Australia.
12 OzGrav-Swinburne, Centre for Astrophysics & Supercomputing, Swinburne University of Technology, Melbourne, 3122, VIC, Australia.
13 Advanced Visualisation Laboratory, Digital Research Innovation Capability Platform, Swinburne University of Technology, Melbourne, 3122, VIC, Australia.
14 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, H3A 2B4, QC, Canada.
15 PERFORM Centre, Concordia University, Montreal, H4B 1R6, QC, Canada.
16 École Polytechnique de Montréal, Institut de génie biomédical, Département de Génie électrique, Montreal, H3C 3A7, QC, Canada.
17 Research Center, Montreal Heart Institute, Montreal, H1T 1C8, QC, Canada.
18 Optina Diagnostics, Montreal, H4T 1Z2, QC, Canada.
19 Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Montreal, H4H 1R3, QC, Canada.
20 Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, H4H 1R3, QC, Canada.
21 MoCA Clinic and Institute, Greenfield Park, J4V 2J2, QC, Canada.
22 Clinique ophtalmologique 2121, Montreal, H3H 1G6, QC, Canada.
23 Département de médecine nucléaire, Hôpital Maisonneuve-Rosemont, Montreal, H1T 2M4, QC, Canada.
24 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.
25 Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Melbourne, 3052, VIC, Australia.
26 Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, 3002, VIC, Australia. peterv@unimelb.edu.au.
27 Ophthalmology, Department of Surgery, University of Melbourne, Parkville, 3010, VIC, Australia. peterv@unimelb.edu.au.

Description:

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.

Nat Commun. 2019 Sep 17;10(1):4227

Authors: Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, Sylvestre JP, Rosa-Neto P, Mathotaarachchi S, Gauthier S, Nasreddine ZS, Arbour JD, Rhéaume MA, Beaulieu S, Dirani M, Nguyen CTO, Bui BV, Williamson R, Crowston JG, van Wijngaarden P

Abstract

Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aß), may serve as surrogate markers of brain Aß levels. As Aß has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aß. Significant differences in the retinal reflectance spectra are found between individuals with high Aß burden on brain PET imaging and mild cognitive impairment (n?=?15), and age-matched PET-negative controls (n?=?20). Retinal imaging scores are correlated with brain Aß loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aß in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aß load.

PMID: 31530809 [PubMed - in process]