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Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.

Author(s): DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E...

To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [11C]ABP6...

Article GUID: 33401137
Neural correlates of resilience to the effects of hippocampal atrophy on memory.

Author(s): Belleville S, Mellah S, Cloutier S, Dang-Vu TT, Duchesne S, Maltezos S, Phillips N, Hudon C, CIMA-Q group...

INTRODUCTION: Cognitive reserve can be defined as a property of the brain that enables an individual to sustain cognitive performance in spite of age-related neural changes. This study uses brain i...

Article GUID: 33360019
Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures

Author(s): Simó M; Gurtubay-Antolin A; Vaquero L; Bruna J; Rodríguez-Fornells A;

No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of...

Article GUID: 29387526
Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy.

Author(s): Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C

Neuroimage Clin. 2018;20:71-84 Authors: Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C

Article GUID: 30094158
Pre-treatment EEG signal variability is associated with treatment success in depression.

Author(s): Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB

Neuroimage Clin. 2018;17:368-377 Authors: Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB

Article GUID: 29159049
Title:Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
Authors:Simó M,  Gurtubay-Antolin A,  Vaquero L,  Bruna J,  Rodríguez-Fornells A, 
Link:https://pubmed.ncbi.nlm.nih.gov/29387526/
DOI:10.1016/j.nicl.2017.12.032
Category:Neuroimage Clin
PMID:29387526
Dept Affiliation: MLNP
1 Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain; Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet-IDIBELL, 08907 Barcelona, Spain. Electronic address: msimo@iconcologia.net.
2 Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
3 Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain; Laboratory for Motor Learning and Neural Plasticity, Concordia University, HUB 1R6 Montreal, QC, Canada.
4 Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet-IDIBELL, 08907 Barcelona, Spain.
5 Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain; Dept. of Cognition, Development and Education Psychology, University of Barcelona, Campus Bellvitge, L'Hospitalet de Llobregat, 08907 Barcelona, Spain; Catalan Institution for Research and Advanced Studies, ICREA, 08010 Barcelona, Spain.

Description:

No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C +) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C -) prior to chemotherapy and a healthy control group (HC). Seventeen SCLC (C +) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C -) and eighteen HC. Between 20 and 30% of patients in both lung cancer groups (C + and C -) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC. Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population.