Keyword search (3,619 papers available)


Combating childhood overweight and obesity: The role of Olympic Movement and bodily movement

Author(s): Tam BT; Wan K; Santosa S; Cai Z;

With over 420 million children (aged 0-19 years) worldwide living with overweight or obesity, the "obesity epidemic" or "globesity" is a defining public health challenge of this generation. While significant efforts have been made to address...

Article GUID: 39991475
A database of magnetic resonance imaging-transcranial ultrasound co-registration

Author(s): Alizadeh M; Collins DL; Kersten-Oertel M; Xiao Y;

Purpose: As a portable and cost-effective imaging modality with better accessibility than Magnetic Resonance Imaging (MRI), transcranial sonography (TCS) has demonstrated its flexibility and potential utility in various clinical diagnostic applications, inc...

Article GUID: 39920905
Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans

Author(s): Costa DN; Santosa S; Jensen MD;

Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the appropriate storage and disposal of glucose and fatty acids....

Article GUID: 39869194
Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach

Author(s): Ali OBK; Vidal A; Grova C; Benali H;

Astrocytes critically shape whole-brain structure and function by forming extensive gap junctional networks that intimately and actively interact with neurons. Despite their importance, existing computational models of whole-brain activity ignore the roles ...

Article GUID: 39804928
Patterns of Cerebellar-Cortical Structural Covariance Mirror Anatomical Connectivity of Sensorimotor and Cognitive Networks

Author(s): Alasmar Z; Chakravarty MM; Penhune VB; Steele CJ;

The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and ...

Article GUID: 39791308
Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement

Author(s): Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann ...

Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understandin...

Article GUID: 39739397
Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology

Author(s): Hrtonova V; Nejedly P; Travnicek V; Cimbalnik J; Matouskova B; Pail M; Peter-Derex L; Grova C; Gotman J; Halamek J; Jurak P; Brazdil M; Klim...

Introduction: Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack...

Article GUID: 39608298
Feeling safe: a critical look at the effect of neighborhood safety features and perceptions on childhood symptoms of depression

Author(s): Infantino E; Barnett TA; Côté-Lussier C; Van Hulst A; Henderson M; Mathieu ME; Sabiston C; Kakinami L;...

Background: Physical characteristics and perceptions of an environment can have enduring effects on one's mental health. The present study aimed to determine whether a set of measures of neighb...

Article GUID: 39604905
The Immediate Effect of a Single Treatment of Neuromuscular Electrical Stimulation with the StimaWELL 120MTRS System on Multifidus Stiffness in Patients with Chronic Low Back Pain

Author(s): Wolfe D; Dover G; Boily M; Fortin M;

Background/objectives: Individuals with chronic low back pain (CLBP) have altered lumbar multifidus stiffness properties compared to healthy controls. Although neuromuscular electrical stimulation (NMES) application to the multifidus might affect stiffness,...

Article GUID: 39594260
Title:Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach
Authors:Ali OBK,  Vidal A,  Grova C,  Benali H, 
Link:https://pubmed.ncbi.nlm.nih.gov/39804928/
DOI:10.1371/journal.pcbi.1012683
Category:
PMID:39804928
Dept Affiliation: SOH
1 Physics Department, Concordia University, Montreal, Canada.
2 Electrical and Computer Engineering Department, Concordia University, Montreal, Canada.
3 Laboratoire de Mathématiques et Modélisation d'Evry (LAMME), Université Evry, CNRS, Université Paris-Saclay, France.
4 Multimodal Functional Imaging Lab, Department of Physics, Concordia School of Health, Concordia University, Montreal, Canada.
5 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montreal, Canada.
6 INSERM U1146, Paris, France.

Description:

Astrocytes critically shape whole-brain structure and function by forming extensive gap junctional networks that intimately and actively interact with neurons. Despite their importance, existing computational models of whole-brain activity ignore the roles of astrocytes while primarily focusing on neurons. Addressing this oversight, we introduce a biophysical neural mass network model, designed to capture the dynamic interplay between astrocytes and neurons via glutamatergic and GABAergic transmission pathways. This network model proposes that neural dynamics are constrained by a two-layered structural network interconnecting both astrocytic and neuronal populations, allowing us to investigate astrocytes' modulatory influences on whole-brain activity and emerging functional connectivity patterns. By developing a simulation methodology, informed by bifurcation and multilayer network theories, we demonstrate that the dialogue between astrocytic and neuronal networks manifests over fast-slow fluctuation mechanisms as well as through phase-amplitude connectivity processes. The findings from our research represent a significant leap forward in the modeling of glial-neuronal collaboration, promising deeper insights into their collaborative roles across health and disease states.