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Author(s): Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J;...
Coronary artery disease (CAD), the leading cause of mortality worldwide, is increasingly recognized for its impact on brain health and cognition, yet the mechanisms linking CAD to vascular and meta...
Article GUID: 41452711
Author(s): Hervé V; KaAli OB; Benali H; Brouillette J;
Background: One of the main neuropathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid-beta oligomers (Aßo), which begins in the brain approximately 15 years prior to the onset of clinical symptoms. Aßo-induced neuronal hyper...
Article GUID: 41436083
Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; ...
Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD)....
Article GUID: 41433447
Author(s): Gurve D; Centen AP; Slack PJ; Dang-Vu TT; Belleville S; Anderson ND; Montero-Odasso M; Nygaard HB; Chertkow H; Feldman HH; Brewster PWH; Lim...
Background: Older adults experience considerable day-to-day variability in cognitive function. We aimed to test the hypothesis that this is in part related to sleep, and determine which EEG sleep f...
Article GUID: 41434309
Author(s): Lamontagne-Kam D; Rahimabadi A; Bello DG; Lavallée-Beaulieu M; Fermawi AE; Bonenfant L; Nanci A; Benali H; Brouillette J;...
Background: Tau pathology is an important neuropathological marker of Alzheimer's Disease (AD) and correlates closely with neurodegeneration and cognitive decline. To date, much of the work exa...
Article GUID: 41435278
Author(s): Rousseau PN; Bazin PL; Steele CJ;
Article GUID: 41420671
Author(s): Kaeja M; Gajiyeva L; Iturria-Medina Y; Villringer A; Sehm B; Steele C;
Background: Stroke is a leading cause of death and disability, with proprioceptive impairments affecting up to 64% of survivors. These impairments hinder sensorimotor recovery, significantly impacting poststroke quality of life. Proprioception depends on an...
Article GUID: 41392885
Author(s): Chan V; Gausper A; Liu A; Andras LM; Illingworth KD; Skaggs DL; Imbeault R; Dufresne J; Parent S; Deschênes S; Roy-Beaudry M; Legler J; Benaroch L; Pirshahid AA; Serhan O; Cheng D; Bartley D; Carey...
Article GUID: 41386990
Author(s): Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ;
The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a m...
Article GUID: 41353310
| Title: | Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans |
| Authors: | Costa DN, Santosa S, Jensen MD, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/39869194/ |
| DOI: | 10.1152/physrev.00008.2024 |
| Category: | |
| PMID: | 39869194 |
| Dept Affiliation: | SOH
1 Mayo Clinic, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Rochester, Minnesota, USA. 2 Department of Health, Kinesiology and Applied Physiology, Concordia University, Montréal, Québec, Canada. 3 Metabolism, Obesity, and Nutrition Lab, School of Health, Concordia University, Montréal, Québec, Canada. |
Description: |
Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the appropriate storage and disposal of glucose and fatty acids. The use of sophisticated calorimetry, tracer, and imaging techniques have provided insight into the complex metabolism of these substrates showing that the regulation of these processes varies tremendously throughout the day, from the overnight fasting condition to meal ingestion, to the effects of physical activity. The sexual dimorphism in substrate metabolism is most readily observed in how fatty acids are stored and mobilized. The objective of this review is to provide a comprehensive and critical summary of the reported sex-differences in the mobilization, oxidation and storage of fat and carbohydrate in adipose tissue and skeletal muscle. We will describe how adipose tissue lipolysis differs between sexes, and how this varies between fed, fasted and exercise conditions. We will also review what is known about endogenous and exogenous fatty acid storage in adipose tissue and muscle, as well as how oxidation compares between men and women in response to exercise. What has been learned about the cellular level regulation of these processes will be described. Although glucose metabolism exhibits fewer differences between men and women, we will also review the existing knowledge on this topic. |
