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Author(s): Jäger AP; Steele CJ; Dreyer FR; Osterloh MR; Sadlon A; Nikulin V; Mohr B; Pulvermüller F;
Background: Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-depe...
Article GUID: 40927858
Author(s): Saputra ST; Van Hulst A; Henderson M; Brugiapaglia S; Faustini C; Kakinami L;
Background: A dual-energy x-ray absorptiometry (DXA)-derived phenotype classification based on fat mass and muscle mass has been developed for adults. We extended this to a paediatric population. Methods: Children's (= 17 years) DXA data in NHANES (n =...
Article GUID: 40878792
Author(s): Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; St...
Patients with coronary artery disease (CAD) face an increased risk of cognitive impairment, dementia, and stroke. While white matter (WM) lesions are frequently reported in patients with CAD, the e...
Article GUID: 40829939
Author(s): Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;
Introduction: Adipose tissue inflammation, driven in part by immune cells, may contribute to the elevated type 2 diabetes risk in adults with childhood-onset obesity (CO) compared to those with adult-onset obesity (AO). Weight loss can modify adipose tissue...
Article GUID: 40831565
Author(s): Pollock D; Hasanoff S; McBride G; Kanukula R; Tricco AC; Khalil H; Campbell F; Jia RM; Alexander L; Peters M; Vieira AM; Aromataris E; Nunn ...
Introduction: Scoping reviews, mapping reviews and evidence and gap maps (collectively known as 'big picture reviews') in health continue to gain popularity within the evidence ecosystem. T...
Article GUID: 40759523
Author(s): Hosseininasabnajar F; Kakinami L;
Loss of brain tissues and cognitive abilities are natural processes of aging, but longitudinal studies are limited. We explored the longitudinal association between global and regional brain measures with cognitive abilities among individuals with normal co...
Article GUID: 40739300
Author(s): Carter F; Anwander A; Johnson M; Goucha T; Adamson H; Friederici AD; Lutti A; Gauthier CJ; Weiskopf N; Bazin PL; Steele CJ;...
The study of brain structure and change in neuroscience is commonly conducted using macroscopic morphological measures of the brain such as regional volume or cortical thickness, providing little i...
Article GUID: 40705745
Author(s): Di Giovanni DA; Kersten-Oertel M; Drouin S; Collins DL;
Purpose: Image-guided neurosurgery demands precise depth perception to minimize cognitive burden during intricate navigational tasks. Existing evaluation methods rely heavily on subjective user feedback, which can be biased and inconsistent. This study uses...
Article GUID: 40650801
Author(s): Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;...
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effe...
Article GUID: 40646404
| Title: | Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans |
| Authors: | Costa DN, Santosa S, Jensen MD, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/39869194/ |
| DOI: | 10.1152/physrev.00008.2024 |
| Category: | |
| PMID: | 39869194 |
| Dept Affiliation: | SOH
1 Mayo Clinic, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Rochester, Minnesota, USA. 2 Department of Health, Kinesiology and Applied Physiology, Concordia University, Montréal, Québec, Canada. 3 Metabolism, Obesity, and Nutrition Lab, School of Health, Concordia University, Montréal, Québec, Canada. |
Description: |
Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the appropriate storage and disposal of glucose and fatty acids. The use of sophisticated calorimetry, tracer, and imaging techniques have provided insight into the complex metabolism of these substrates showing that the regulation of these processes varies tremendously throughout the day, from the overnight fasting condition to meal ingestion, to the effects of physical activity. The sexual dimorphism in substrate metabolism is most readily observed in how fatty acids are stored and mobilized. The objective of this review is to provide a comprehensive and critical summary of the reported sex-differences in the mobilization, oxidation and storage of fat and carbohydrate in adipose tissue and skeletal muscle. We will describe how adipose tissue lipolysis differs between sexes, and how this varies between fed, fasted and exercise conditions. We will also review what is known about endogenous and exogenous fatty acid storage in adipose tissue and muscle, as well as how oxidation compares between men and women in response to exercise. What has been learned about the cellular level regulation of these processes will be described. Although glucose metabolism exhibits fewer differences between men and women, we will also review the existing knowledge on this topic. |
