| Keyword search (3,619 papers available) | |
Author(s): Tam BT; Wan K; Santosa S; Cai Z;
With over 420 million children (aged 0-19 years) worldwide living with overweight or obesity, the "obesity epidemic" or "globesity" is a defining public health challenge of this generation. While significant efforts have been made to address...
Article GUID: 39991475
Author(s): Alizadeh M; Collins DL; Kersten-Oertel M; Xiao Y;
Purpose: As a portable and cost-effective imaging modality with better accessibility than Magnetic Resonance Imaging (MRI), transcranial sonography (TCS) has demonstrated its flexibility and potential utility in various clinical diagnostic applications, inc...
Article GUID: 39920905
Author(s): Costa DN; Santosa S; Jensen MD;
Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the appropriate storage and disposal of glucose and fatty acids....
Article GUID: 39869194
Author(s): Ali OBK; Vidal A; Grova C; Benali H;
Astrocytes critically shape whole-brain structure and function by forming extensive gap junctional networks that intimately and actively interact with neurons. Despite their importance, existing computational models of whole-brain activity ignore the roles ...
Article GUID: 39804928
Author(s): Alasmar Z; Chakravarty MM; Penhune VB; Steele CJ;
The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and ...
Article GUID: 39791308
Author(s): Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann ...
Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understandin...
Article GUID: 39739397
Author(s): Hrtonova V; Nejedly P; Travnicek V; Cimbalnik J; Matouskova B; Pail M; Peter-Derex L; Grova C; Gotman J; Halamek J; Jurak P; Brazdil M; Klim...
Introduction: Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack...
Article GUID: 39608298
Author(s): Infantino E; Barnett TA; Côté-Lussier C; Van Hulst A; Henderson M; Mathieu ME; Sabiston C; Kakinami L;...
Background: Physical characteristics and perceptions of an environment can have enduring effects on one's mental health. The present study aimed to determine whether a set of measures of neighb...
Article GUID: 39604905
Author(s): Wolfe D; Dover G; Boily M; Fortin M;
Background/objectives: Individuals with chronic low back pain (CLBP) have altered lumbar multifidus stiffness properties compared to healthy controls. Although neuromuscular electrical stimulation (NMES) application to the multifidus might affect stiffness,...
Article GUID: 39594260
| Title: | Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans |
| Authors: | Costa DN, Santosa S, Jensen MD, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/39869194/ |
| DOI: | 10.1152/physrev.00008.2024 |
| Category: | |
| PMID: | 39869194 |
| Dept Affiliation: | SOH
1 Mayo Clinic, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Rochester, Minnesota, USA. 2 Department of Health, Kinesiology and Applied Physiology, Concordia University, Montréal, Québec, Canada. 3 Metabolism, Obesity, and Nutrition Lab, School of Health, Concordia University, Montréal, Québec, Canada. |
Description: |
Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the appropriate storage and disposal of glucose and fatty acids. The use of sophisticated calorimetry, tracer, and imaging techniques have provided insight into the complex metabolism of these substrates showing that the regulation of these processes varies tremendously throughout the day, from the overnight fasting condition to meal ingestion, to the effects of physical activity. The sexual dimorphism in substrate metabolism is most readily observed in how fatty acids are stored and mobilized. The objective of this review is to provide a comprehensive and critical summary of the reported sex-differences in the mobilization, oxidation and storage of fat and carbohydrate in adipose tissue and skeletal muscle. We will describe how adipose tissue lipolysis differs between sexes, and how this varies between fed, fasted and exercise conditions. We will also review what is known about endogenous and exogenous fatty acid storage in adipose tissue and muscle, as well as how oxidation compares between men and women in response to exercise. What has been learned about the cellular level regulation of these processes will be described. Although glucose metabolism exhibits fewer differences between men and women, we will also review the existing knowledge on this topic. |
