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Author(s): Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;...
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effe...
Article GUID: 40646404
Author(s): Cai Z; Pellegrino G; Spilkin A; Delaire E; Uji M; Abdallah C; Lina JM; Fecteau S; Grova C;
Background: The relationship between task-related hemodynamic activity and brain excitability is poorly understood in humans as it is technically challenging to combine simultaneously non-invasive brain stimulation and neuroimaging modalities. Cortical exci...
Article GUID: 40567300
Author(s): Turner L; Wanasinghe AI; Brunori P; Santosa S;
In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammati...
Article GUID: 40533358
Author(s): Abdallah C; Thomas J; Aron O; Avigdor T; Jaber K; Doležalová I; Mansilla D; Nevalainen P; Parikh P; Singh J; Beniczky S; Kahane P; Minotti L...
Objective: Epilepsy surgery needs predictive features that are easily implemented in clinical practice. Previous studies are limited by small sample sizes, lack of external validation, and complex ...
Article GUID: 40519108
Author(s): Caron FP; Martin Smith C; Naghdi N; Iorio OC; Bertrand C; Fortin M;
Purpose: The purpose of this study was to investigate the relationship between different characteristics of the Thoracolumbar Fascia (TLF) (e.g., length, epimuscular fat distribution) with pain status and lumbar extension strength in a sample of participant...
Article GUID: 40498329
Author(s): Chauhan RV; Demetriades AK; Boerger TF; Lantz JM; Treanor C; Kalsi-Ryan S; Kumar V; Wood L; Plener J; Wilson N; Fortin M; Ammendolia C; Paus...
Introduction: Evidence on degenerative cervical myelopathy (DCM) has frequently focussed on surgical management, overlooking the role of non-surgical clinicians. Their contributions in the patient ...
Article GUID: 40487873
Author(s): Avigdor T; Peter-Derex L; Ho A; Schiller K; Wang Y; Abdallah C; Delaire E; Jaber K; Travnicek V; Grova C; Frauscher B;...
Although rapid eye movement (REM) sleep is often thought of as a singular state, it consists of two substates, phasic and tonic REM, defined by the presence (respectively absence) of bursts of rapi...
Article GUID: 40394955
Author(s): Delaire É; Vincent T; Cai Z; Machado A; Hugueville L; Schwartz D; Tadel F; Cassani R; Bherer L; Lina JM; Pélégrini-Issac M; Grova C;...
Significance: Understanding the brain's complex functions requires multimodal approaches that combine data from various neuroimaging techniques. Functional near-infrared spectroscopy (fNIRS) of...
Article GUID: 40375973
Author(s): Pinto SM; Cheung JPY; Samartzis D; Karppinen J; Zheng YP; Pang MYC; Fortin M; Wong AYL;
Background: Although individuals with chronic low back pain (CLBP) show increased fatty infiltration in the lumbar multifidus muscle (LMM), it remains unclear whether LMM changes are related to clinical outcomes (such as pain and disability) after consideri...
Article GUID: 40376565
| Title: | Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans |
| Authors: | Costa DN, Santosa S, Jensen MD, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/39869194/ |
| DOI: | 10.1152/physrev.00008.2024 |
| Category: | |
| PMID: | 39869194 |
| Dept Affiliation: | SOH
1 Mayo Clinic, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Rochester, Minnesota, USA. 2 Department of Health, Kinesiology and Applied Physiology, Concordia University, Montréal, Québec, Canada. 3 Metabolism, Obesity, and Nutrition Lab, School of Health, Concordia University, Montréal, Québec, Canada. |
Description: |
Adult males and females have markedly different body composition, energy expenditure, and have different degrees of risk for metabolic diseases. A major aspect of metabolic regulation involves the appropriate storage and disposal of glucose and fatty acids. The use of sophisticated calorimetry, tracer, and imaging techniques have provided insight into the complex metabolism of these substrates showing that the regulation of these processes varies tremendously throughout the day, from the overnight fasting condition to meal ingestion, to the effects of physical activity. The sexual dimorphism in substrate metabolism is most readily observed in how fatty acids are stored and mobilized. The objective of this review is to provide a comprehensive and critical summary of the reported sex-differences in the mobilization, oxidation and storage of fat and carbohydrate in adipose tissue and skeletal muscle. We will describe how adipose tissue lipolysis differs between sexes, and how this varies between fed, fasted and exercise conditions. We will also review what is known about endogenous and exogenous fatty acid storage in adipose tissue and muscle, as well as how oxidation compares between men and women in response to exercise. What has been learned about the cellular level regulation of these processes will be described. Although glucose metabolism exhibits fewer differences between men and women, we will also review the existing knowledge on this topic. |
