| Keyword search (3,791 papers available) | |
Author(s): Di Giovanni DA; Kersten-Oertel M; Drouin S; Collins DL;
Purpose: Image-guided neurosurgery demands precise depth perception to minimize cognitive burden during intricate navigational tasks. Existing evaluation methods rely heavily on subjective user feedback, which can be biased and inconsistent. This study uses...
Article GUID: 40650801
Author(s): Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;...
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effe...
Article GUID: 40646404
Author(s): Cai Z; Pellegrino G; Spilkin A; Delaire E; Uji M; Abdallah C; Lina JM; Fecteau S; Grova C;
Background: The relationship between task-related hemodynamic activity and brain excitability is poorly understood in humans as it is technically challenging to combine simultaneously non-invasive brain stimulation and neuroimaging modalities. Cortical exci...
Article GUID: 40567300
Author(s): Turner L; Wanasinghe AI; Brunori P; Santosa S;
In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammati...
Article GUID: 40533358
Author(s): Abdallah C; Thomas J; Aron O; Avigdor T; Jaber K; Doležalová I; Mansilla D; Nevalainen P; Parikh P; Singh J; Beniczky S; Kahane P; Minotti L...
Objective: Epilepsy surgery needs predictive features that are easily implemented in clinical practice. Previous studies are limited by small sample sizes, lack of external validation, and complex ...
Article GUID: 40519108
Author(s): Caron FP; Martin Smith C; Naghdi N; Iorio OC; Bertrand C; Fortin M;
Purpose: The purpose of this study was to investigate the relationship between different characteristics of the Thoracolumbar Fascia (TLF) (e.g., length, epimuscular fat distribution) with pain status and lumbar extension strength in a sample of participant...
Article GUID: 40498329
Author(s): Chauhan RV; Demetriades AK; Boerger TF; Lantz JM; Treanor C; Kalsi-Ryan S; Kumar V; Wood L; Plener J; Wilson N; Fortin M; Ammendolia C; Paus...
Introduction: Evidence on degenerative cervical myelopathy (DCM) has frequently focussed on surgical management, overlooking the role of non-surgical clinicians. Their contributions in the patient ...
Article GUID: 40487873
Author(s): Avigdor T; Peter-Derex L; Ho A; Schiller K; Wang Y; Abdallah C; Delaire E; Jaber K; Travnicek V; Grova C; Frauscher B;...
Although rapid eye movement (REM) sleep is often thought of as a singular state, it consists of two substates, phasic and tonic REM, defined by the presence (respectively absence) of bursts of rapi...
Article GUID: 40394955
Author(s): Delaire É; Vincent T; Cai Z; Machado A; Hugueville L; Schwartz D; Tadel F; Cassani R; Bherer L; Lina JM; Pélégrini-Issac M; Grova C;...
Significance: Understanding the brain's complex functions requires multimodal approaches that combine data from various neuroimaging techniques. Functional near-infrared spectroscopy (fNIRS) of...
Article GUID: 40375973
| Title: | Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults |
| Authors: | Ferland MC, Wang R, Therrien-Blanchet JM, Remahi S, Côté S, Fréchette AJ, Dang-Vu TT, Liu H, Lepage JF, Théoret H, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/40646404/ |
| DOI: | 10.1007/s11682-025-01043-4 |
| Category: | |
| PMID: | 40646404 |
| Dept Affiliation: | PERFORM
1 Department of Psychology, Faculté des Arts et Sciences, Université de Montréal, Montréal, Canada. 2 Changping Laboratory & Peking University, Beijing, China. 3 Department of Pediatrics, Faculty of Medicine and Health Sciences, Université Sherbrooke Hospital Research Center, Sherbrooke, Canada. 4 Center for Studies in Behavioral Neurobiology and Perform Center, Department of Health, Kinesiology and Applied Physiology, Concordia University, Montréal, Canada. 5 Research Center, Institut Universitaire de Gériatrie de Montréal, Montréal, Canada. 6 Department of Psychology, Faculté des Arts et Sciences, Université de Montréal, Montréal, Canada. hugo.theoret@umontreal.ca. |
Description: |
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effects of a single dose of lorazepam on brain functional connectivity at rest is not known. In this placebo-controlled, crossover study, twenty healthy adult participants (9 women; 26.2 ± 5.2 years) underwent two resting-state fMRI (rs-fMRI) scans following administration of either lorazepam (2.5 mg) or placebo. Imaging data were analyzed using an individual brain network parcellation approach and differences in functional connectivity among 78 individual-specific ROIs were estimated. Compared to placebo, functional connectivity was reduced following administration of lorazepam between the left medial paracentral lobule and left temporal pole and between the left posterior cingulate sulcus and right cuneus. Reduced connectivity within higher-order cognitive networks partly supports what has been reported for other benzodiazepines such as midazolam and alprazolam. However, differences across benzodiazepines - possibly due to pharmacokinetics, dosage and receptor selectivity - underscore the need for further research. |
